Placebo and opioid analgesia - Imaging a shared neuronal network
Placebo and opioid analgesia - Imaging a shared neuronal network
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DOI：
10.1126/science.1067176
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发表时间：
2002-03-01
期刊：
影响因子：
56.9
通讯作者：
Ingvar, M
中科院分区：
文献类型：
--
作者：
Petrovic, P;Kalso, E;Ingvar, M
已有研究表明，安慰剂镇痛既涉及高级认知网络，也涉及内源性阿片系统。嘴前扣带回皮质(RACC)和脑干参与阿片类药物的镇痛，提示这些结构在安慰剂镇痛中也有类似的作用。使用正电子发射断层扫描，我们证实阿片类药物和安慰剂止痛都与rACC中活动增加有关。我们还观察到，在阿片类药物和安慰剂止痛期间，rACC和脑干的活动之间存在协同变化，但在仅有疼痛的情况下则没有。这些发现表明了安慰剂和阿片类药物镇痛的相关神经机制。
It has been suggested that placebo analgesia involves both higher order cognitive networks and endogenous opioid systems. The rostral anterior cingulate cortex (rACC) and the brainstem are implicated in opioid analgesia, suggesting a similar role for these structures in placebo analgesia. Using positron emission tomography, we confirmed that both opioid and placebo analgesia are associated with increased activity in the rACC. We also observed a covariation between the activity in the rACC and the brainstem during both opioid and placebo analgesia, but not during the pain-only condition. These findings indicate a related neural mechanism in placebo and opioid analgesia.