Critical periods and Autism Spectrum Disorders, a role for sleep.
Critical periods and Autism Spectrum Disorders, a role for sleep.
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DOI：
10.1016/j.nbscr.2022.100088
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发表时间：
2023-05
影响因子：
--
通讯作者：
Peixoto, Lucia
中科院分区：
文献类型：
--
作者：
Medina, Elizabeth;Peterson, Sarah;Ford, Kaitlyn;Singletary, Kristan;Peixoto, Lucia
大脑发育依赖于经验和基因定义的程序。某些大脑回路特别容易接受外部刺激，从而导致可塑性提高的时间窗口被称为“关键期”。睡眠被认为对大脑的正常发育至关重要。重要的是，研究表明，睡眠增强了关键期的可塑性，并促进了哺乳动物大脑发育中的经验依赖性突触修剪。因此，关键时期的正常可塑性取决于睡眠。相对于典型的发展，自闭症谱系障碍（ASD）中入睡和保持睡眠的问题发生率更高。在这篇综述中，我们探讨了睡眠，关键期可塑性和ASD之间的潜在联系。首先，我们回顾了关键期可塑性在典型发育中的重要性以及睡眠在这一过程中的作用。接下来，我们总结了在高置信度ASD基因候选者的啮齿动物模型中ASD与突触可塑性缺陷之间的联系。然后，我们表明，高置信度的ASD啮齿动物模型，显示睡眠缺陷也显示可塑性缺陷。鉴于睡眠对关键期可塑性的重要性，了解ASD中突触可塑性，睡眠和大脑发育之间的联系至关重要。然而，缺乏研究ASD小鼠模型关键时期的睡眠或可塑性的研究。因此，我们强调迫切需要考虑在睡眠和可塑性神经发育障碍的研究发展轨迹。突触可塑性依赖于充足的睡眠，特别是在大脑发育的关键时期。我们提供了一个全面的审查ASD小鼠模型连接基因突变和脑可塑性缺陷。导致可塑性缺陷的ASD突变通常与睡眠缺陷同时存在，当睡眠已经进行时。未来使用ASD小鼠模型的研究应该从生命早期开始同时研究睡眠和可塑性。
Brain development relies on both experience and genetically defined programs. Time windows where certain brain circuits are particularly receptive to external stimuli, resulting in heightened plasticity, are referred to as “critical periods”. Sleep is thought to be essential for normal brain development. Importantly, studies have shown that sleep enhances critical period plasticity and promotes experience-dependent synaptic pruning in the developing mammalian brain. Therefore, normal plasticity during critical periods depends on sleep. Problems falling and staying asleep occur at a higher rate in Autism Spectrum Disorder (ASD) relative to typical development. In this review, we explore the potential link between sleep, critical period plasticity, and ASD. First, we review the importance of critical period plasticity in typical development and the role of sleep in this process. Next, we summarize the evidence linking ASD with deficits in synaptic plasticity in rodent models of high-confidence ASD gene candidates. We then show that the high-confidence rodent models of ASD that show sleep deficits also display plasticity deficits. Given how important sleep is for critical period plasticity, it is essential to understand the connections between synaptic plasticity, sleep, and brain development in ASD. However, studies investigating sleep or plasticity during critical periods in ASD mouse models are lacking. Therefore, we highlight an urgent need to consider developmental trajectory in studies of sleep and plasticity in neurodevelopmental disorders. Synaptic plasticity depends on adequate amounts of sleep, especially during critical periods of brain development. We provide a thorough review of ASD mouse models linking genetic mutations and brain plasticity deficits. ASD mutations that lead to plasticity deficits often co-present with sleep deficits, when sleep have been performed. Future studies using ASD mouse models should study sleep and plasticity simultaneously starting in early life.
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影响因子：
3.5
作者：
Altafaj, X;Dierssen, M;Estivill, X
通讯作者：
Estivill, X
影响因子：
6.2
作者：
Bozdagi O;Sakurai T;Papapetrou D;Wang X;Dickstein DL;Takahashi N;Kajiwara Y;Yang M;Katz AM;Scattoni ML;Harris MJ;Saxena R;Silverman JL;Crawley JN;Zhou Q;Hof PR;Buxbaum JD
通讯作者：
Buxbaum JD
影响因子：
30.8
作者：
Caubit, Xavier;Gubellini, Paolo;Andrieux, Joris;Roubertoux, Pierre L.;Metwaly, Mehdi;Jacq, Bernard;Fatmi, Ahmed;Had-Aissouni, Laurence;Kwan, Kenneth Y.;Salin, Pascal;Carlier, Michele;Lieden, Agne;Rudd, Eva;Shinawi, Marwan;Vincent-Delorme, Catherine;Cuisset, Jean-Marie;Lemaitre, Marie-Pierre;Abderrehamane, Fatimetou;Duban, Benedicte;Lemaitre, Jean-Francois;Woolf, Adrian S.;Bockenhauer, Detlef;Severac, Dany;Dubois, Emeric;Zhu, Ying;Sestan, Nenad;Garratt, Alistair N.;Goff, Lydia Kerkerian-Le;Fasano, Laurent
通讯作者：
Fasano, Laurent
影响因子：
6.2
作者：
Bozdagi O;Tavassoli T;Buxbaum JD
通讯作者：
Buxbaum JD
DOI：
10.1038/npp.2015.26
发表时间：
2015-06
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Aida T;Yoshida J;Nomura M;Tanimura A;Iino Y;Soma M;Bai N;Ito Y;Cui W;Aizawa H;Yanagisawa M;Nagai T;Takata N;Tanaka KF;Takayanagi R;Kano M;Götz M;Hirase H;Tanaka K
通讯作者：
Tanaka K