An overview of protein adsorption on metal oxide coatings for biomedical implants
An overview of protein adsorption on metal oxide coatings for biomedical implants
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DOI：
10.1016/j.surfcoat.2013.04.028
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发表时间：
2013-10-25
影响因子：
5.4
通讯作者：
Rodil, S. E.
中科院分区：
文献类型：
--
作者：
Silva-Bermudez, P.;Rodil, S. E.
对生物材料进行表面改性可以提高现有金属植入装置的性能和寿命。金属氧化物涂层代表了一种潜在的表面改性，以增强生物相容性和其他生物相关性能，如金属植入物的耐生物腐蚀性。为了设计具有定制特性的生物相容性金属氧化物涂层，有必要更深入地了解外来表面-生物相互作用，例如蛋白质-表面相互作用，这是在植入物-生物环境接触时发生的初始过程。通过了解这种相互作用以及氧化膜的物理化学性质对其的影响，就有可能为从血液到骨接触植入物的各种植入器械正确设计氧化物涂层。沿着的文件，不同的例子，以支持蛋白质表面相互作用的重要性，作为生物相容性和生物功能性的第一个指标，以及现有的蛋白质吸附和金属氧化物薄膜的物理化学表面性质之间的相关性。(C)2013爱思唯尔有限公司版权所有。
Surface modification of biomaterials can improve the performance and lifetime of current metallic implantable devices. Metal oxide coatings represent a potential surface modification to enhance the biocompatibility and other biological-related properties, such as the biocorrosion resistance of the metallic implants. In order to design biocompatible metal oxide coatings with tailored properties, it is necessary to get a deeper understanding of the foreign surface-biological interactions, such as the protein-surface interaction, which is the initial process occurring at the implant-biological ambiance contact. By understanding such interaction and the influence of the physicochemical properties of the oxide films on it; then, it might be possible to properly design oxide coatings for a large variety of implant devices from blood to bone contacting implants. Along the paper, different examples are presented in order to support the importance of the protein-surface interaction as a first indicator of biocompatibility and biofunctionality, as well as the existing correlation between protein adsorption and the physicochemical surface properties of metal oxide films. (C) 2013 Elsevier B.V. All rights reserved.