PPARγ and the global map of adipogenesis and beyond.
PPARγ and the global map of adipogenesis and beyond.
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PPARγ和全球脂肪形成及其他图。
DOI：
10.1016/j.tem.2014.04.001
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Mandrup S
中科院分区：
文献类型：
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作者：
Lefterova MI;Haakonsson AK;Lazar MA;Mandrup S
过氧化物酶体增殖物激活受体γ（Peroxisome proliferator-activated receptor γ，PPARγ）是核受体超家族中的一员，是脂肪细胞分化和代谢的主要调控因子。在这里，我们回顾了最近的突破，在染色质背景下的PPARγ基因调控和功能的理解。现在清楚的是，在脂肪形成过程中，多种转录因子联合诱导PPARγ，并且其他转录因子与PPARγ合作以确保脂肪细胞特异性基因组结合和功能。我们讨论了这在其他表达PPARγ的细胞（如巨噬细胞）中是如何不同的，以及这些全基因组机制是如何在物种间保留的，尽管特异性结合位点有一定的保守性。这些新出现的考虑为我们了解PPARγ功能以及脂肪细胞发育和生理学提供了信息。
Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor superfamily of ligand-dependent transcription factors which functions as a master regulator of adipocyte differentiation and metabolism. Here we review recent breakthroughs in the understanding of PPARγ gene regulation and function in a chromatin context. It is now clear that multiple transcription factors team up to induce PPARγ during adipogenesis, and that other transcription factors cooperate with PPARγ to ensure adipocyte-specific genomic binding and function. We discuss how this differs in other PPARγ-expressing cells such as macrophages, and how these genome-wide mechanisms are preserved across species despite modest conservation of specific binding sites. These emerging considerations inform our understanding of PPARγ function as well as adipocyte development and physiology.