Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations.
Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations.
复制标题
DOI：
10.1158/2159-8290.cd-20-1165
复制
发表时间：
2021-03
期刊：
影响因子：
28.2
通讯作者：
Meyerson M
中科院分区：
文献类型：
--
作者：
Carrot-Zhang J;Soca-Chafre G;Patterson N;Thorner AR;Nag A;Watson J;Genovese G;Rodriguez J;Gelbard MK;Corrales-Rodriguez L;Mitsuishi Y;Ha G;Campbell JD;Oxnard GR;Arrieta O;Cardona AF;Gusev A;Meyerson M
人们对遗传性肺癌的风险，尤其是不吸烟者，知之甚少。来自拉丁美洲的1153例肺癌的基因组和祖先分析揭示了美洲原住民血统与其躯体景观之间的惊人关联，包括肿瘤突变负担（TMB），以及EGFR、KRAS和STK11的特定驱动突变。与全球祖先相关性相比，当地印第安人祖先风险评分与EGFR突变频率的相关性更强，这表明生殖系遗传（而不是环境暴露）是这些差异的基础。
Inherited lung cancer risk, particularly in non-smokers, is poorly understood. Genomic and ancestry analysis of 1153 lung cancers from Latin America revealed striking associations between Native American ancestry and their somatic landscape, including tumor mutational burden (TMB), and specific driver mutations in EGFR, KRAS, and STK11. A local Native American ancestry risk score was more strongly correlated with EGFR mutation frequency compared to global ancestry correlation, suggesting that germline genetics (rather than environmental exposure) underlie these disparities.