Regulation of mRNA Translation by Signaling Pathways
Regulation of mRNA Translation by Signaling Pathways
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DOI：
10.1101/cshperspect.a012252
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发表时间：
2012-11-01
影响因子：
7.2
通讯作者：
Topisirovic, Ivan
中科院分区：
文献类型：
--
作者：
Roux, Philippe P.;Topisirovic, Ivan
mRNA翻译是细胞中最耗能的过程。此外，它在控制基因表达中起着关键作用，因此受到严格调控。响应于各种细胞外刺激和细胞内线索，信号传导途径通过调节磷酸化状态并因此调节翻译机制组分的活性来诱导mRNA翻译的定量和定性变化。在这项工作中，我们专注于磷脂酰肌醇3-激酶（PI 3 K）/AKT和丝裂原活化蛋白激酶（MAPK）途径，因为它们强烈地参与了体内平衡中的翻译调节，而它们的功能障碍与人类疾病（包括癌症）中的异常翻译有关。
mRNA translation is the most energy consuming process in the cell. In addition, it plays a pivotal role in the control of gene expression and is therefore tightly regulated. In response to various extracellular stimuli and intracellular cues, signaling pathways induce quantitative and qualitative changes in mRNA translation by modulating the phosphorylation status and thus the activity of components of the translational machinery. In this work we focus on the phosphoinositide 3-kinase (PI3K)/AKT and the mitogen-activated protein kinase (MAPK) pathways, as they are strongly implicated in the regulation of translation in homeostasis, whereas their malfunction has been linked to aberrant translation in human diseases, including cancer.