HLA‐DR‐like Antigens in the Epithelium of the Human Small Intestine
HLA‐DR‐like Antigens in the Epithelium of the Human Small Intestine
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人类小肠上皮细胞中的 HLA-DR 样抗原
DOI：
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发表时间：
1980
影响因子：
3.7
通讯作者：
E. Thorsby
中科院分区：
文献类型：
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作者：
H. Scott;B. Solheim;P. Brandtzaeg;E. Thorsby
采用间接免疫荧光法，用抗B淋巴细胞HLA-DR-抗原的兔抗血清对人胃肠道不同部位的乙醇固定、石蜡包埋组织标本切片进行染色。在正常小肠的柱状细胞中可见一种斑片状的特异性染色反应，从绒毛顶部向隐窝逐渐减弱。在结肠或胃上皮中未检测到HLA-DR样抗原，而在整个胃肠道中，固有层和毛细血管壁中具有淋巴细胞和组织细胞形态的细胞被特异性染色。
Sections of ethanol‐fixed, paraffin‐embedded tissue specimens from different parts of the human gastrointestinal tract were stained by an indirect immunofluorescence method with a rabbit antiserum to HLA‐DR‐antigens from B lymphocytes. A specific staining reaction was seen in a patchy pattern apically in the columnar cells of the normal small intestine, decreasing in intensity from the top of the villi towards the crypts. No HLA‐DR‐like antigens could he detected in colon or stomach epithelium, whereas cellS with the morphology of lymphocytes and histiocytes in the lamina propria and also capillary walls were specifically stained throughout the gastrointestinal tract.