Resolving adjacent nanophosphors of different concentrations by excitation-based cone-beam X-ray luminescence tomography
Resolving adjacent nanophosphors of different concentrations by excitation-based cone-beam X-ray luminescence tomography
复制标题
通过基于激发的锥形束 X 射线发光断层扫描分辨不同浓度的相邻纳米磷光体
DOI：
10.1364/boe.8.003952
复制
发表时间：
2017-09-01
影响因子：
3.4
通讯作者：
Lu, Hongbing
中科院分区：
文献类型：
--
作者：
Gao, Peng;Pu, Huangsheng;Lu, Hongbing
锥束X射线发光计算机断层扫描（CB-XLCT）最近被提议作为一种新的分子成像方式。通过锥形束 X 射线在体内或体外激发纳米磷光体，它可以有效地获得物体的解剖学和功能性断层扫描图像。然而，CB-XLCT 逆问题的不适定性会降低图像质量，并且难以解析不同浓度的相邻发光目标，而这对于监测纳米颗粒代谢和药物输送至关重要。针对这一问题，本研究提出了一种结合主成分分析的多电压激励成像方案。通过定制的 CB-XLCT 系统对物理体模进行的成像实验表明，可以有效分辨不同浓度且边距为 0 mm 的两个相邻目标。 (C) 2017年美国光学学会
Cone-beam X-ray luminescence computed tomography (CB-XLCT) has been proposed as a new molecular imaging modality recently. It can obtain both anatomical and functional tomographic images of an object efficiently, with the excitation of nanophosphors in vivo or in vitro by cone-beam X-rays. However, the ill-posedness of the CB-XLCT inverse problem degrades the image quality and makes it difficult to resolve adjacent luminescent targets with different concentrations, which is essential in the monitoring of nanoparticle metabolism and drug delivery. To address this problem, a multi-voltage excitation imaging scheme combined with principal component analysis is proposed in this study. Imaging experiments performed on physical phantoms by a custom-made CB-XLCT system demonstrate that two adjacent targets, with different concentrations and an edge-to-edge distance of 0 mm, can be effectively resolved. (C) 2017 Optical Society of America