p53 and ageing: too much of a good thing?
p53 and ageing: too much of a good thing?
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DOI：
10.1002/bies.10111
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发表时间：
2002-07-01
期刊：
影响因子：
4
通讯作者：
Kirkwood, TBL
中科院分区：
文献类型：
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作者：
Kirkwood, TBL
泰纳等人最近的一份报告。((1))表明p53对长寿有害携带p53突变的杂合子小鼠明显增强了野生型蛋白质的稳定性，表现出更短的寿命和更快的衰老，同时也发生了更少的肿瘤。这符合细胞衰老是为了更好地防止癌细胞无限增殖而付出的代价的想法。但其他研究表明，DNA修复介导的抗癌保护与衰老之间存在强烈的正相关。那么，我们如何利用这些新数据来全面了解衰老的机制呢？(C)2002 Wiley Periodicals，Inc.
A recent report by Tyner et al.((1)) suggests that p53 is bad for longevity. Heterozygotic mice carrying a p53 mutation that apparently enhances the stability of the wild-type protein showed shorter lifespans and faster ageing while also developing fewer tumours. This fits with the idea that cellular ageing is the price paid for better protection against unlimited proliferation of cancer cells. But other work shows that there is a strong positive association between DNA repair-mediated protection against cancer and ageing. So what are we to make of the new data with regard to overall understanding of the mechanisms of ageing? (C) 2002 Wiley Periodicals, Inc.