Single-molecule detection sensitivity using planar integrated optics on a chip
Single-molecule detection sensitivity using planar integrated optics on a chip
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DOI：
10.1364/ol.31.002136
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发表时间：
2006-07-15
期刊：
影响因子：
3.6
通讯作者：
Hawkins, Aaron R.
中科院分区：
文献类型：
--
作者：
Yin, Dongliang;Deamer, David W.;Hawkins, Aaron R.
我们提出了一种基于相交固体和液体芯波导的微加工平面网络的单分子检测的全平面集成光学方法。我们研究液芯反谐振反射光波导中染料分子的荧光，并演示亚皮升激发体积、通过多个泵浦波导的并行激发以及单分子检测灵敏度集成硅光子学与溶液中的单分子检测相结合，创建了一个紧凑、坚固且灵敏的平台，可在从原子物理到生命的众多领域中应用 科学。 (c) 2006 年美国光学学会。
We present a fully planar integrated optical approach to single-molecule detection based on microfabricated planar networks of intersecting solid and liquid-core waveguides. We study fluorescence from dye molecules in liquid-core antiresonant reflecting optical waveguides, and demonstrate subpicoliter excitation volumes, parallel excitation through multiple pump waveguides, and single-molecule detection sensitivity Integrated silicon photonics combined with single-molecule detection in solution create a compact, robust, and sensitive platform that has applications in numerous fields ranging from atomic physics to the life sciences. (c) 2006 Optical Society of America.