Overexpression of matrix metalloproteinase-7 (MMP-7) correlates with tumor proliferation, and a poor prognosis in non-small cell lung cancer
Overexpression of matrix metalloproteinase-7 (MMP-7) correlates with tumor proliferation, and a poor prognosis in non-small cell lung cancer
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DOI：
10.1016/j.lungcan.2007.07.005
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发表时间：
2007-12-01
期刊：
影响因子：
5.3
通讯作者：
Huang, Cheng-long
中科院分区：
文献类型：
--
作者：
Liu, Dage;Nakano, Jun;Huang, Cheng-long
背景资料：基质金属蛋白酶-7（MMP-7）是MMP家族的一员，在肿瘤的发生、侵袭和转移中起重要作用。本研究根据非小细胞肺癌（non-small cell lung cancer，NSCLC）的临床特点、生物学标志物及Wnt 1的表达，对MMP-7在NSCLC中的表达进行了回顾性研究。免疫组化检测MMP-7表达、Ki-67增殖指数、肿瘤血管生成和Wnt 1表达。结果：MMP-7阳性表达率为51.7%（76/76）。MMP-7在鳞癌中的表达明显高于腺癌（P < 0.0001）。Ki-67增殖指数在MMP-7阳性组明显高于MMP-7阴性组（P = 0.0003）。然而，MMP-7的表达与细胞凋亡或血管生成的关系没有差异。MMP-7表达与Wnt 1表达呈显著正相关（r = 0.426，P < 0.0001）。MMP-7阳性NSCLC患者的总生存率显著低于MMP-7阴性NSCLC患者（P=0.0018）。考克斯回归分析也显示MMP-7状态是一个重要的预后因素（风险比，2.187; P = 0.0023）。此外，Wnt 1可能在调节肿瘤内MMP-7的表达中起关键作用。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Background: Matrix metatloporteinase-7 (MMP-7) is a member of the MMP family, and it has been reported to play an important rote in tumorigenesis, invasion and metastasis. We performed a retrospective study on the MMP-7 expression in non-small cell lung cancer (NSCLC) according to the clinical characteristics, biological markers and the Wnt1 expression.Patients and methods: One hundred forty-seven postsurgical NSCLC patients were investigated. Immunohistochemistry was performed to evaluate the MMP-7 expression, the Ki-67 proliferation index, tumor angiogenesis and the Wnt1 expression. The TUNEL method was performed to investigate tumor apoptosis.Results: Seventy-six carcinomas (51.7%) were MMP-7-positive. The MMP-7 expression was significantly higher in squamous cell carcinomas than in adenocarcinomas (P < 0.0001). The Ki-67 proliferation index was significantly higher in MMP-7-positvie tumors than in MMP-7-negative tumors (P = 0.0003). However, there was no difference in the MMP-7 expression in relation to apoptosis or angiogenesis. Regarding its regulation, the MMP-7 expression significantly correlated with the Wnt1 expression (r = 0.426, P < 0.0001). The overall survival was significantly lower in patients with MMP-7-positive NSCLCs than in those with MMP-7-negative NSCLCs (P=0.0018). A Cox regression analyses also demonstrated MMP-7 status to be a significant prognostic factor (hazard ratio, 2.187; P = 0.0023).Conclusions: The overexpression of MMP-7 was associated with tumor proliferation, and a poor prognosis in NSCLCs. In addition, Wnt1 may play a critical role in regulating the intratumoral MMP-7 expression. (c) 2007 Elsevier Ireland Ltd. All rights reserved.