Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle -: the PARSIFAL study
Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle -: the PARSIFAL study
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DOI：
10.1111/j.1398-9995.2005.00939.x
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发表时间：
2006-04-01
期刊：
影响因子：
12.4
通讯作者：
Pershagen, G
中科院分区：
文献类型：
--
作者：
Alfvén, T;Braun-Fahrländer, C;Pershagen, G
背景：近几十年来，过敏性疾病的患病率迅速增加，特别是在儿童中。为了进行充分的预防，不仅要识别风险因素，还要识别可能的保护因素。本研究的目的是比较农场儿童、人源性家庭儿童和参考儿童之间过敏性疾病和致敏的患病率，目的是确定可能预防过敏性疾病的因素。方法：该研究采用横断面设计，包括14893名来自农场家庭的5-13岁儿童，在奥地利、德国、荷兰、瑞典和瑞士的人视家庭（从Steiner学校招募）和参考儿童中进行了研究。一个详细的问卷调查完成，过敏原特异性IgE测定blood.Results：长大的农场被发现有一个保护作用，对所有的研究成果，自我报告，如鼻结膜炎，喘息，过敏性湿疹和哮喘和致敏（过敏原特异性IgE >= 0.35 kU/l）。与其参考相比，农场儿童当前鼻结膜炎症状的校正比值比（OR）为0.50（95%置信区间（CI）0.38-0.65），特应性致敏为0.53（95% CI 0.42-0.67）。与参考儿童相比，Steiner学校儿童的过敏症状和致敏的患病率也较低，但差异不太明显，并且在国家之间不一致，当前鼻结膜炎症状的校正OR为0.69（95% CI 0.56-0.86）和特应性致敏0.73（95% CI 0.58-0.92）。这项研究表明，在农场长大，在较小的程度上，过一种人择性的生活方式可以保护儿童免受致敏和过敏性疾病的影响。
Background: The prevalence of allergic diseases has increased rapidly in recent decades, particularly in children. For adequate prevention it is important not only to identify risk factors, but also possible protective factors. The aim of this study was to compare the prevalence of allergic diseases and sensitization between farm children, children in anthroposophic families, and reference children, with the aim to identify factors that may protect against allergic disease.Methods: The study was of cross-sectional design and included 14 893 children, aged 5-13 years, from farm families, anthroposophic families (recruited from Steiner schools) and reference children in Austria, Germany, the Netherlands, Sweden and Switzerland. A detailed questionnaire was completed and allergen-specific IgE was measured in blood.Results: Growing up on a farm was found to have a protective effect against all outcomes studied, both self-reported, such as rhinoconjunctivitis, wheezing, atopic eczema and asthma and sensitization (allergen specific IgE >= 0.35 kU/l). The adjusted odds ratio (OR) for current rhinoconjunctivitis symptoms was 0.50 (95% confidence interval (CI) 0.38-0.65) and for atopic sensitization 0.53 (95% CI 0.42-0.67) for the farm children compared to their references. The prevalence of allergic symptoms and sensitization was also lower among Steiner school children compared to reference children, but the difference was less pronounced and not as consistent between countries, adjusted OR for current rhinoconjunctivitis symptoms was 0.69 (95% CI 0.56-0.86) and for atopic sensitization 0.73 (95% CI 0.58-0.92).Conclusions: This study indicates that growing up on a farm, and to a lesser extent leading an anthroposophic life style may confer protection from both sensitization and allergic diseases in childhood.