The relationship between tumour size and expression of prognostic markers in benign and malignant canine mammary tumours
The relationship between tumour size and expression of prognostic markers in benign and malignant canine mammary tumours
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DOI：
10.1111/j.1476-5829.2009.00193.x
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发表时间：
2009-12-01
影响因子：
2.1
通讯作者：
Cassali, G. D.
中科院分区：
文献类型：
--
作者：
Ferreira, E.;Bertagnolli, A. C.;Cassali, G. D.
肿瘤大小被认为是癌症患者临床分期的最重要决定因素之一。本研究的目的是评估肿瘤大小作为雌性犬乳腺肿瘤分化指标的价值。肿瘤，淋巴结转移（TNM）系统，根据原发病灶的大小，其扩散到区域淋巴结的程度和是否存在远处转移，适用于120只诊断为乳腺肿瘤的雌性犬。对38例乳腺癌石蜡切片进行免疫组化染色，研究乳腺癌的预后和预测标志物。估计了110只雌性犬的Kaplan-Meier生存曲线。较大的肿瘤（T3）大多是恶性的，并表现出较低的孕激素受体表达和较高的细胞增殖标志物的表达。具有大肿瘤肿块的雌性犬的总体生存时间较短。本研究强调了肿瘤大小作为雌性犬乳腺肿瘤预后指标的重要性。
Tumour size is considered one of the most important determinants of clinical staging in cancer patients. The aim of this study was to assess the value of tumour size as an indicator of the differentiation of mammary neoplasias in female dogs. The tumour, nodes metastates (TNM) system, based on primary lesion size, the extent of its dissemination to regional lymph nodes and the presence or absence of distant metastases, was applied to 120 female dogs diagnosed with mammary neoplasias. Paraffin blocks from 38 cases were selected and studied by immunohistochemical staining for prognostic and predictive markers of breast cancer. The Kaplan-Meier survival curve was estimated for 110 female dogs. Larger tumours (T3) were mostly malignant and showed lower expression of progesterone receptor and higher expression of cellular proliferation markers. Global survival time was shorter in female dogs with large tumour masses. This study highlights the importance of tumour size as a prognostic indicator of mammary neoplasias in female dogs.