Prevalence of Herpes Simplex Virus Type 2 in Different Risk Groups: Thirty Years after the Onset of HIV
Prevalence of Herpes Simplex Virus Type 2 in Different Risk Groups: Thirty Years after the Onset of HIV
复制标题
不同危险人群中 2 型单纯疱疹病毒的患病率：艾滋病毒发病三十年后
作者：
C. Reinheimer;H. Doerr
背景：单纯疱疹病毒2型（HSV 2）是一种性传播疾病，可导致终身持续感染。目的：测定德国某集体抗HSV 2-IgG的血清阳性率。我们评估了德国的血清学状况，指出了HSV 2感染按时间顺序传播的趋势，并将我们的研究结果置于全球范围内。方法：采用ELISA法对来自德国美因河畔法兰克福大学医院的29,694例患者的血清样本进行抗HSV 2-IgG筛查。我们评估了五个定义的组，包括儿科（PED），妇科（GYN），皮肤科（DER），精神科（PSY）和艾滋病毒/艾滋病（HIV）患者的患者。结果如下：我们回顾性评价了抗HSV 2-IgG的总体血清阳性率为13.6%（95%CI 13.1-14.1），女性（15.9%，95%CI 15.4-16.5）的水平显著高于男性（11.4%，95%CI 10.9-11.9）。在HIV中检测到最高的血清阳性率（34.7%，95% CI 30.3-39.3）。在PED中观察到的发生率最低（9.9%，95% CI 9.4-10.6），2000年1月1日至2011年1月1日期间分娩时估计有18例感染。结论：单纯疱疹病毒2型感染在德国广泛存在，对新生儿有巨大的健康风险。因此，应加强公众对HSV 2的认知，宣传保护性性交。
Background: Herpes simplex virus type 2 (HSV2) is a sexually transmitted disease causing a lifelong persisting infection. Objective: To determine the seroprevalence of anti-HSV2-IgG in a German collective. We evaluate the German serological status, point out trends in the chronological spread of HSV2 infection, and position our findings in a global context. Methods: Serum samples from 29,694 patients at the University Hospital Frankfurt am Main, Germany, were screened for anti-HSV2-IgG using ELISA. We evaluated five defined groups containing patients from the departments of pediatrics (PED), gynecology (GYN), dermatology (DER), psychiatrics (PSY) and patients suffering from HIV/AIDS (HIV). Results: We retrospectively evaluated an overall seropositivity to anti-HSV2-IgG of 13.6% (95% CI 13.1–14.1), with a significantly higher level in females (15.9%, 95% CI 15.4–16.5) than in males (11.4%, 95% CI 10.9–11.9). The highest seroprevalence was detected in HIV (34.7%, 95% CI 30.3–39.3). The lowest rate was observed in PED (9.9%, 95% CI 9.4–10.6) with an estimated number of 18 infections at delivery between 1/1/2000 and 1/1/2011. Conclusions: HSV2 infections are widespread in Germany with a tremendous health risk for newborns. Therefore, the public’s perception of HSV2 should be strengthened and protected sexual intercourse should be propagated.
HSV-2感染的有症状和无症状的人中，单纯疱疹病毒的生殖器脱落。
影响因子：
120.7
作者：
Tronstein, Elizabeth;Johnston, Christine;Huang, Meei-Li;Selke, Stacy;Magaret, Amalia;Warren, Terri;Corey, Lawrence;Wald, Anna
通讯作者：
Wald, Anna
DOI：
10.1176/appi.ajp.2009.09030361
发表时间：
2010-03
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Brown AS;Derkits EJ
通讯作者：
Derkits EJ