Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: Discovery of a new leucine-rich nuclear export signal site
Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: Discovery of a new leucine-rich nuclear export signal site
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DOI：
10.1016/j.bbrc.2009.11.115
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发表时间：
2010-01-08
影响因子：
3.1
通讯作者：
Uyeda, Kosaku
中科院分区：
文献类型：
--
作者：
Fukasawa, Masashi;Ge, Qing;Uyeda, Kosaku
碳水化合物反应元件结合蛋白（ChREBP）负责通过协调将糖酵解丙酮酸转化为脂肪生成的酶的表达将膳食碳水化合物转化为肝脏中的储存脂肪。ChREBP在高糖下的激活主要是核定位和转录，而在低糖下的失活主要是从核向胞浆输出。本文报道了一个新的ChREBP核输出信号位点（NES 1）。这些信号一起为ChREBP提供了两个内斯序列，先前报道的NES 2和现在的新NES 1都与CRM 1（输出蛋白）相互作用，用于碳水化合物反应元件结合蛋白的核输出。爱思唯尔公司出版
Carbohydrate response element binding protein (ChREBP) is responsible for conversion of dietary carbohydrate to storage fat in liver by coordinating expression of the enzymes that channel glycolytic pyruvate into lipogenesis. The activation of ChREBP in response to high glucose is nuclear localization and transcription, and the inactivation of ChREBP under low glucose involves export from the nucleus to the cytosol. Here we report a new nuclear export signal site ("NES1") of ChREBP. Together these signals provide ChREBP with two NES sequences, both the previously reported NES2 and now the new NES1 coordinate to interact together with CRM1 (exportin) for nuclear export of the carbohydrate response element binding protein. Published by Elsevier Inc.