Diffuse osteosclerosis as a presentation of recurrent breast cancer: role of endothelin 1.
Diffuse osteosclerosis as a presentation of recurrent breast cancer: role of endothelin 1.
复制标题
弥漫性骨硬化是乳腺癌复发的表现：内皮素的作用 1。
DOI：
10.1007/s00198-019-04998-5
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Shaker,JL
中科院分区：
文献类型：
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作者：
Zarnecki,KG;Kristianto,J;Charlson,J;Wilson,B;Blank,RD;Shaker,JL
摘要我们报告一位有乳癌病史的46岁女性，表现为弥漫性肌痛、骨痛及骨质疏松。她被发现患有复发性乳腺癌，产生内皮素-1。内皮素-1被认为有助于骨质疏松引起的乳腺癌。MethodsAlthough骨髓活检没有发现乳腺癌，她开发的皮肤病变转移性乳腺癌一致。她最终死于疾病进展。在尸检内皮素-1的免疫组化进行了一段从L5椎体。ResultsThe节从L5椎体显示小病灶的细胞符合转移癌和突出的scarcine反应。免疫组化内皮素-1呈强阳性。结论复发性乳腺癌可表现为弥漫性骨质增生。内皮素-1可能是一种旁分泌因子，负责增加骨形成和骨形成。
SummaryWe report a 46-yr-old woman with a history of breast cancer who presented with diffuse myalgias, bone pain, and osteosclerosis. She was found to have recurrent breast cancer producing endothelin-1.IntroductionAcquired osteosclerosis can be caused by various disorders. Endothelin -1 is believed to contribute to osteosclerosis caused by breast cancer.MethodsAlthough the bone marrow biopsy did not reveal breast cancer, she developed skin lesions consistent with metastatic breast cancer. She ultimately died from progressive disease. At autopsy immunohistochemistry for endothelin-1 was performed on a section from the L5 vertebral body.ResultsThe section from the L5 vertebral body showed small foci of cells consistent with metastatic carcinoma and a prominent sclerotic response. Immunohistochemistry for endothelin-1 was strongly positive.ConclusionsRecurrent breast cancer may present with diffuse osteosclerosis. Endothelin-1 may be a paracrine factor responsible for increased bone formation and osteosclerosis.