Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates alpha-helix formation of the polyQ tract but suppresses its aggregation
Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates alpha-helix formation of the polyQ tract but suppresses its aggregation
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结构和动力学研究表明,ataxin-7 的富含 Ala 区域启动了 PolyQ 束的 α 螺旋形成,但抑制了其聚集
作者:
Hong Jun-Ye;Wang Dong-Dong;Xue Wei;Yue Hong-Wei;Yang Hui;Jiang Lei-Lei;Wang Wen-Ning;Hu Hong-Yu