HIPPOCAMPECTOMY IMPAIRS THE MEMORY OF RECENTLY, BUT NOT REMOTELY, ACQUIRED TRACE EYEBLINK CONDITIONED-RESPONSES
HIPPOCAMPECTOMY IMPAIRS THE MEMORY OF RECENTLY, BUT NOT REMOTELY, ACQUIRED TRACE EYEBLINK CONDITIONED-RESPONSES
复制标题
DOI：
10.1037/0735-7044.109.2.195
复制
发表时间：
1995-04-01
影响因子：
1.9
通讯作者：
THOMPSON, RF
中科院分区：
文献类型：
--
作者：
KIM, JJ;CLARK, RE;THOMPSON, RF
新西兰雄性家兔（Oryctolagus cuniculus）进行了训练的轨迹眨眼条件反射范例，使用250毫秒的音调条件刺激，100毫秒的喷气非条件刺激，和500毫秒的跟踪间隔。兔子在学习后1天或1个月接受双侧海马抽吸。对照组包括时间匹配的假手术和新皮质抽吸兔。当重新测试的痕迹范例，学习后1天海马愿望的兔子显着和实质性损害的痕迹条件反射的保留。相比之下，接受海马抽吸训练后1个月的兔子保留了与对照组相当的微量条件反射。此外，小脑切除术对延迟眨眼条件反射的保持没有影响。因此，海马似乎是必要的保留最近收购，但不是远程收购，跟踪条件反射。
New Zealand male rabbits (Oryctolagus cuniculus) were trained on a trace eyeblink conditioning paradigm using a 250-ms tone conditioned stimulus, a 100-ms airpuff unconditioned stimulus, and a 500-ms trace interval. Rabbits received bilateral hippocampal aspirations either 1 day or 1 month after learning. Controls consisted of time-matched sham-operated and neocortical aspirated rabbits. When retested on the trace paradigm, rabbits with hippocampal aspirations 1 day after learning were significantly and substantially impaired in the retention of trace conditioned responses. In contrast, rabbits that received hippocampal aspirations 1 month after training retained trace conditioned responses at a level comparable to that of the controls. Moreover, hippocampectomy had no effect on the retention of delay eyeblink conditioning. Thus, the hippocampus appears to be necessary for the retention of recently acquired, but not remotely acquired, trace conditioned responses.