Selective and sensitive detection of cyanate using 3-amino-2-naphthoic acid-based turn-on fluorescence probe
Selective and sensitive detection of cyanate using 3-amino-2-naphthoic acid-based turn-on fluorescence probe
复制标题
使用基于 3-氨基-2-萘酸的开启荧光探针选择性、灵敏地检测氰酸盐
DOI：
10.1007/s00216-019-01843-w
复制
发表时间：
2019-06-01
影响因子：
4.3
通讯作者：
Tang, Xinjing
中科院分区：
文献类型：
--
作者：
Feng, Jie;Zhong, Jiale;Tang, Xinjing
The cyanate anion (CNO-), formed spontaneously within cells from urea and carbamoyl phosphate, usually functions as a biomarker of some diseases such as chronic kidney disease. Therefore, accurate determination of CNO- is highly demanded. Herein, a 3-amino-2-naphthoic acid-based turn-on fluorescence probe was developed for specific detection of CNO-. Upon the addition of sodium cyanate, the weak-fluorescent 3-amino-2-naphthoic acid could react with CNO-, which triggered intense emission of green fluorescence. And up to 9-fold fluorescence enhancement was observed. The fluorescence enhancement ratios displayed a good linear relationship with the concentrations of CNO- in the range of 0.5-200M. The high selectivity and sensitivity for CNO- detection were investigated with the detection limit as low as 260nM. The probe was further successfully applied to determine CNO- in real samples such as tap water, human urine and serum samples, which offered a promising approach in practical applications.
