Antimicrobial Peptides from Plants
Antimicrobial Peptides from Plants
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DOI：
10.1080/07352689709701952
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发表时间：
1997
影响因子：
6.9
通讯作者：
W. Broekaert;B. Cammue;M. D. De Bolle;K. Thevissen;G. De Samblanx;R. Osborn;K. Nielson
中科院分区：
文献类型：
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作者：
W. Broekaert;B. Cammue;M. D. De Bolle;K. Thevissen;G. De Samblanx;R. Osborn;K. Nielson
摘要具有抗菌活性的多肽存在于大多数植物中。迄今为止分离的所有植物抗微生物肽都含有偶数个半胱氨酸（4、6或8个），它们都通过二硫键成对连接，从而为肽提供高稳定性。根据一级结构水平上的同源性，植物抗菌肽可分为硫素类、植物防御素类、脂质转运蛋白类、脉型和结型抗菌肽类。已经获得了这些肽家族的一个或多个成员的详细三维结构信息。迄今为止研究的所有抗微生物肽似乎在靶微生物的质膜水平上发挥其抗微生物作用，但不同的肽类型可能通过不同的机制起作用。抗菌肽可以存在于所有植物器官中。在无应激的器官中，抗菌肽通常在外细胞中最丰富。
Abstract Peptides with antimicrobial properties are present in most if not all plant species. All plant antimicrobial peptides isolated so far contain even numbers of cysteines (4, 6, or 8), which are all pairwise connected by disulfide bridges, thus providing high stability to the peptides. Based on homologies at the primary structure level, plant antimicrobial peptides can be classified into distinct families including thionins, plant defensins, lipid transfer proteins, and he vein- and knottin-type antimicrobial peptides. Detailed three-dimensional structure information has been obtained for one or more members of these peptide families. All antimicrobial peptides studied thus far appear to exert their antimicrobial effect at the level of the plasma membrane of the target microorganism, but the different peptide types are likely to act via different mechanisms. Antimicrobial peptides can occur in all plant organs. In unstressed organs, antimicrobial peptides are usually most abundant in the outer cell ...