Freeze-Casting of Porous Biomaterials: Structure, Properties and Opportunities
Freeze-Casting of Porous Biomaterials: Structure, Properties and Opportunities
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DOI：
10.3390/ma3031913
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发表时间：
2010-03-17
期刊：
影响因子：
3.4
通讯作者：
Deville S
中科院分区：
文献类型：
--
作者：
Deville S
在过去的几年里，多孔材料的冷冻铸造受到了极大的关注。这种简单的方法，其中材料悬浮液被简单地冷冻，然后升华，提供了具有独特的多孔结构的材料，其中孔隙率几乎是冷冻溶剂晶体的直接复制品。本文综述了多孔材料制备过程及其多孔结构在生物材料中的应用。特别令人感兴趣的是材料的结构和过程的多功能性，这可以很容易地控制和应用于生物材料应用。需要仔细控制起始配方和加工条件，以控制结构的完整性和所得性能。需要进一步的体外和体内研究来验证这种新型多孔材料的潜力。
The freeze-casting of porous materials has received a great deal of attention during the past few years. This simple process, where a material suspension is simply frozen and then sublimated, provides materials with unique porous architectures, where the porosity is almost a direct replica of the frozen solvent crystals. This review focuses on the recent results on the process and the derived porous structures with regards to the biomaterials applications. Of particular interest is the architecture of the materials and the versatility of the process, which can be readily controlled and applied to biomaterials applications. A careful control of the starting formulation and processing conditions is required to control the integrity of the structure and resulting properties. Further in vitro and in vivo investigations are required to validate the potential of this new class of porous materials.