Selective suppression of Toll-like receptor 4 activation by chemokine receptor 4
Selective suppression of Toll-like receptor 4 activation by chemokine receptor 4
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DOI：
10.1016/j.febslet.2004.12.047
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发表时间：
2005-01-31
期刊：
影响因子：
3.5
通讯作者：
Brunn, GJ
中科院分区：
文献类型：
--
作者：
Kishore, SP;Bungum, MK;Brunn, GJ
Toll样受体4(TLR4)对脂多糖(LPS)的应答被认为是抵抗感染的关键。由于异常的TLR4信号可能引发炎症状态，如脓毒症综合征，我们寻找正常细胞的一种成分，可能提供对TLR4激活的局部控制。我们发现，阻断趋化因子受体4(CXCR4)功能的抗体增强了TLR4信号，而CXCR4表达增加或增加CXCR4配体SDF-1则抑制了内毒素诱导的TLR4信号。这些发现表明，CXCR4可以对TLR4进行局部控制，并提示了抑制TLR4功能的新的治疗方法的可能性。(C)2004年欧洲生化学会联合会。爱思唯尔出版，版权所有。
The response of Toll-like receptor 4 (TLR4) to lipopolysaccharide (LPS) is thought vital for resisting infection. Since aberrant TLR4 signaling may initiate inflammatory conditions such as the sepsis syndrome, we sought a component of normal cells that might provide local control of TLR4 activation. We found that antibodies that block chemokine receptor 4 (CXCR4) function enhanced TLR4 signaling, while increased expression of CXCR4 or addition of the CXCR4 ligand SDF-1 suppressed TLR4 signaling induced by LPS. These findings suggest that CXCR4 could exert local control of TLR4 and suggest the possibility of new therapeutic approaches to suppression of TLR4 function. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.