Why are some protein structures so common?
Why are some protein structures so common?
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DOI：
10.1073/pnas.93.8.3341
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发表时间：
1996-04-16
影响因子：
11.1
通讯作者：
Goldstein, RA
中科院分区：
文献类型：
--
作者：
Govindarajan, S;Goldstein, RA
许多生物蛋白被观察到折叠成有限数量的结构基序之一。考虑到蛋白质快速折叠的需求，以及作为天然结构的函数，满足这些需求的容易程度，我们可以解释为什么某些结构在序列相似性可以忽略不计的蛋白质中反复观察到。这项工作对理解蛋白质序列-结构关系以及蛋白质进化具有重要意义。
Many biological proteins are observed to fold into one of a limited number of structural motifs. By considering the requirements imposed on proteins by their need to fold rapidly, and the ease with which such requirements can be fulfilled as a function of the native structure, we can explain why certain structures are repeatedly observed among proteins with negligible sequence similarity. This work has implications for the understanding of protein sequence-structure relationships as well as protein evolution.