Weight loss in Parkinson's disease
Weight loss in Parkinson's disease
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DOI：
10.1007/s00415-006-7009-0
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发表时间：
2006-12-01
影响因子：
6
通讯作者：
Kashihara, Kenichi
中科院分区：
文献类型：
--
作者：
Kashihara, Kenichi
帕金森病（PD）患者的体重减轻是常见的。能量摄入减少和/或能量消耗增加被假定为原因。吞咽困难、厌食和胃肠道功能障碍可能是能量摄入减少的原因;而强直、震颤和左旋多巴诱导的运动障碍可能会增加能量消耗。左旋多巴可增强葡萄糖代谢，导致能量消耗增加。抑郁症、抗帕金森病药物和医学并发症（如肺炎和恶性肿瘤）也可能促进PD患者的体重减轻。这些因素的不同程度的组合，特别是在晚期PD中，可能会导致体重减轻。这种体重减轻与营养不良有关，营养不良可能会加速感染和褥疮，加速运动、行为和自主神经损伤，从而破坏一个人的生活质量。还必须注意运动症状，以防止或逆转PD患者的体重减轻。
Weight loss is frequent in patients with Parkinson's disease (PD). Reduced energy intake and/or increased energy expenditure have been postulated as the cause. Dysphagia, anorexia, and gastrointestinal dysfunction may be possible causes of reduced energy intake; whereas, rigidity, tremor, and levodopa-induced dyskinesia may increase energy expenditure. Levodopa may enhance glucose metabolism resulting in enhanced energy expenditure. Depression, anti-parkinsonian drugs, and medical complications such as pneumonia and malignancies also may facilitate weight loss in PD. Combinations of various degrees of these factors, especially in advanced PD, may produce weight loss. Such weight loss is associated with malnutrition which may precipitate infection and decubitis; accelerate motor, behavioral, and autonomic impairment; consequently spoiling one's quality of life. Attention must be paid as well to motor symptoms to prevent or reverse weight loss in PD patients.