A methodological investigation of a flexible surface MRI coil to obtain functional signals from the human olfactory bulb
A methodological investigation of a flexible surface MRI coil to obtain functional signals from the human olfactory bulb
复制标题
DOI：
10.1016/j.jneumeth.2020.108624
复制
发表时间：
2020-02
影响因子：
3
通讯作者：
A. Fournel;E. Iannilli;C. Ferdenzi;A. Werner;Thomas Hummel;Moustafa Bensafi
中科院分区：
文献类型：
--
作者：
A. Fournel;E. Iannilli;C. Ferdenzi;A. Werner;Thomas Hummel;Moustafa Bensafi
哺乳动物的嗅觉始于嗅觉受体的转导，在嗅球中继续广泛的加工，最终在皮质表达。大多数啮齿动物对嗅觉的功能神经解剖学研究都集中在嗅球上，但这种结构是仅针对气味的基本化学特征还是针对更高阶的感知特征尚不清楚。新方法在对人脑的研究通常可以揭示参与更高阶特征提取的情况下，这在嗅球的情况下是不可能的，因为fMRI无法访问。结果一系列实验提供了人类嗅球气味驱动反应的初步证据，并发现这些反应因个体而异。与现有方法和结论相比，目前的初步技术成果使通过考虑从嗅球到联想区域的嗅觉系统来设计新的人类气味fMRI研究成为可能。
BackgroundMammalian olfaction begins with transduction in olfactory receptors, continues with extensive processing in the olfactory bulb, and culminates in cortical representation. Most rodent studies on the functional neuroanatomy of olfaction have concentrated on the olfactory bulb, yet whether this structure is tuned only to basic chemical features of odorants or also to higher-order perceptual features is unclear.New methodWhereas studies of the human brain can typically uncover involvement of higher-order feature extraction, this has not been possible in the case of the olfactory bulb, inaccessible to fMRI. The present study examined whether a novel method of acquisition using a facial coil could overcome this limitation.ResultsA series of experiments provided preliminary evidence of odor-driven responses in the human olfactory bulb, and found that these responses differed between individuals.Comparison with existing methods and conclusionsThe present preliminary technical achievement renders possible to design novel human odor fMRI studies by considering the olfactory system from the olfactory bulb to associative areas.