Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease
Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease
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DOI：
10.1038/sj.ijo.0803726
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发表时间：
2008-02-01
影响因子：
4.9
通讯作者：
Lai, W-T
中科院分区：
文献类型：
--
作者：
Cheng, K-H;Chu, C-S;Lai, W-T
目的：心外膜和腹部脂肪组织最近被证明在冠状动脉粥样硬化中起炎症作用。设计：采集腹部和心外膜脂肪组织样本，检测脂肪细胞因子和促炎性介质的水平。研究对象：46例接受冠状动脉搭桥术的CAD患者和12例接受其他类型的心内直视手术的非CAD对照组。测量：组织中脂肪细胞因子(脂联素，结果：冠心病组组织中肿瘤坏死因子-α、IL-6、瘦素、内脂素水平明显高于正常对照组。此外，在冠心病患者中，腹部脂肪库中这四种细胞因子的组织水平显著高于心外膜脂肪。相反，与对照组相比，腹壁脂肪含量明显低于心外膜脂肪堆积的冠心病患者的脂联素水平显著降低。结论：腹壁肥胖在冠状动脉粥样硬化发病机制中可能比心外膜脂肪起更重要的作用。
Objective: Epicardial and abdominal adipose tissues have recently been demonstrated to play inflammatory roles in coronary atherosclerosis. We sought to compare tissue adipocytokine levels of these two anatomically distinct adipose stores in patients with and without coronary artery diseases (CAD).Design: Samples of abdominal and epicardial fat tissues were harvested to detect the levels of adipocytokines and pro-inflammatory mediators.Subjects: Forty-six patients with CAD who underwent coronary artery bypass surgery and 12 non-CAD control subjects who underwent other types of open-heart surgery.Measurements: Tissue levels of adipocytokines (adiponectin, leptin and visfatin) and proinflammatory mediators (tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6)) were determined by enzyme-linked immunosorbent assay.Results: Tissue levels of TNF-alpha, IL-6, leptin and visfatin were significantly higher in CAD patients relative to control subjects. In addition, significantly higher tissue levels of these four cytokines from abdominal fat depots were found compared to those from epicardial fat in CAD patients. Conversely, in comparison with control subjects, tissue levels of adiponectin were significantly reduced in CAD patients with a significantly lower tissue levels of abdominal than epicardial fat depots demonstrated.Conclusion: Abdominal adiposity may play more significant role than epicardial fat in the pathogenesis of coronary atherosclerosis.