Control of glomerular hypertension by insulin administration in diabetic rats.
Control of glomerular hypertension by insulin administration in diabetic rats.
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通过糖尿病大鼠的胰岛素给药控制肾小球高血压。
DOI：
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发表时间：
1989
影响因子：
15.9
通讯作者：
T. Meyer
中科院分区：
文献类型：
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作者：
J. Scholey;T. Meyer
用链脲佐菌素造成糖尿病的慕尼黑Wistar大鼠和正常对照大鼠进行了微穿刺法研究。糖尿病大鼠每天接受超低浓度胰岛素治疗以维持中度高血糖(约300 mg/dl)。第1组糖尿病大鼠常规微穿刺术后肾小球单肾单位滤过率(SNGFR)增加，肾小球跨毛细血管水力压差和肾小球血浆流量增加。2组糖尿病大鼠静脉注射胰岛素实现急性血糖控制，使肾小球跨毛细血管压力梯度正常化，同时增加肾小球超滤系数，使SNGFR持续升高。在第三组糖尿病大鼠中也观察到了持续的SNGFR升高，尽管跨毛细血管压力梯度正常化，但输入了足够的胰岛素和足够的葡萄糖来维持高血糖。这些研究表明，糖尿病患者的肾小球毛细血管高压是胰岛素缺乏的急性可逆后果，而不是肾脏肥大的结果。
Micropuncture studies were performed in Munich Wistar rats made diabetic with streptozotocin and in normal control rats. Diabetic rats received daily ultralente insulin to maintain moderate hyperglycemia (approximately 300 mg/dl). Group 1 diabetic rats studied after routine micropuncture preparation exhibited elevation of the single nephron glomerular filtration rate (SNGFR) due to increases in the glomerular transcapillary hydraulic pressure difference and glomerular plasma flow rate. In group 2 diabetic rats infusion of insulin to achieve acute blood glucose control normalized the glomerular transcapillary pressure gradient while increasing the glomerular ultrafiltration coefficient, so that SNGFR remained elevated. Persistent elevation of SNGFR despite normalization of the transcapillary pressure gradient was also observed in group 3 diabetic rats infused with insulin plus sufficient dextrose to maintain hyperglycemia. These studies indicate that glomerular capillary hypertension in diabetes is an acutely reversible consequence of insulin deficiency and not the result of renal hypertrophy.
影响因子：
19.6
作者：
Bank,N;Klose,R;Aynedjian,HS;Nguyen,D;Sablay,LB
通讯作者：
Sablay,LB