Maternal smoking promotes chronic obstructive lung disease in the offspring as adults.
Maternal smoking promotes chronic obstructive lung disease in the offspring as adults.
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DOI：
10.1186/2047-783x-14-s4-27
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发表时间：
2009-12-07
影响因子：
4.2
通讯作者：
Gillissen A
中科院分区：
文献类型：
--
作者：
Beyer D;Mitfessel H;Gillissen A
众所周知，在子宫内和/或儿童环境中暴露于烟草烟雾会对肺功能产生不利影响，并以多种方式损害儿童的健康。很少有研究评估了对成年后期COPD发展和疾病严重程度的长期影响。COPD患者进行了采访，使用结构式问卷调查，关于他们的个人以及他们的父母的吸烟习惯。将数据与疾病史（如COPD加重率）及其肺功能数据进行比较。在2003年至2004年期间，COPD患者被招募a）在专门从事肺部医学的私人诊所（n = 133）和B）在医院（n = 158）。75%的父亲和15.4%的母亲经常吸烟。母亲吸烟的COPD患者FEV 1预测值低于母亲无吸烟暴露的COPD患者：39.4 ± 9.5% vs.51.9 ± 6.0%（P = 0.037）。父亲对FEV 1没有影响，无论他们是吸烟者还是非吸烟者。需要住院治疗的重度急性发作率不受父母二手烟暴露的影响。母亲吸烟会对其后代的肺功能产生负面影响，即使在成年后期，当他们患上COPD时也是如此。它甚至强调了积极吸烟的累积效应。COPD的临床病程未受影响。
In utero and/or childhood environmental tobacco smoke exposure is well known to adversely affect lung function and to depreciate child's health in many ways. Fewer studies have assessed the long-term effects on COPD development and disease severity in later adulthood. COPD patients were interviewed using a structured questionnaire regarding their personal as well as the smoking habits of their parents. Data were compared with the disease history, e.g. COPD exacerbation rate, and their lung function data. Between 2003 and 2004 COPD patients were recruited a) in a private practice specialized in pulmonary medicine (n = 133) and b) in a hospital (n = 158). 75% of their fathers and only 15.4 of all mothers smoked regularly. COPD patients from smoking mothers had lower FEV1 predicted than those raised in household without maternal smoking exposure: 39.4 ± 9.5% vs. 51.9 ± 6.0% (P = 0.037). Fathers had no effect on FEV1 regardless if they are smokers or non-smokers. Rate of severe exacerbations requiring hospitalization remained unaffected by parental second hand smoke exposure. Maternal smoking negatively affects lung function of their offspring even in late adulthood when they develop COPD. It even aggravates the cumulative effect of active cigarette consumption. Clinical course of the COPD remained unaffected.
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影响因子：
10
作者：
David, GL;Koh, WP;London, SJ
通讯作者：
London, SJ
影响因子：
5.8
作者：
Landau, Louis I.
通讯作者：
Landau, Louis I.
影响因子：
10
作者：
Gilliland, FD;Berhane, K;Peters, JM
通讯作者：
Peters, JM
影响因子：
5.6
作者：
Eisner, Mark D.;Wang, Yue;Tager, Ira B.
通讯作者：
Tager, Ira B.
影响因子：
4.4
作者：
Lelong, N;Kaminski, M;Bouvier-Colle, MH
通讯作者：
Bouvier-Colle, MH