Characterization of 26 Staphylococcus warneri isolates from orthopedic infections
Characterization of 26 Staphylococcus warneri isolates from orthopedic infections
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DOI：
10.1177/039139881003300903
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发表时间：
2010-09-01
影响因子：
1.7
通讯作者：
Arciola, Carla Renata
中科院分区：
文献类型：
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作者：
Campoccia, Davide;Montanaro, Lucio;Arciola, Carla Renata
瓦纳利葡萄球菌是一种凝固酶阴性葡萄球菌（CNS），常见于人上皮和粘膜菌群。在过去的二十年中，与其他中枢神经系统物种类似，沃纳里氏球菌被报道为一种新的新兴病原体，通常与植入材料的存在有关，能够引起严重感染，但有时甚至在没有异物和被认为具有免疫能力的患者中。目前，关于该物种的发病机制和流行病学仍缺乏科学资料。本研究调查了26例骨科感染的临床分离株，其中一些与植入材料有关，另一些与植入材料无关。自动核分型显示存在5个不同的核蛋白群。除了由单个分离物组成的数量最少的核糖群外，所有其他核糖群都包括至少一种来自与植入材料无关的感染的菌株，这表明即使在没有异物的情况下，假定的感染所必需的毒力因子可能与大多数核糖群类别相同。发现骨科感染涉及具有低抗生素耐药潜力的瓦纳里沙门氏菌菌株，在这方面与新生儿重症监护病房分离的菌株不同，该物种已被描述为主要病原体之一，并表现出惊人的抗生素耐药性。
Staphylococcus warneri is a coagulase negative Staphylococcus (CNS) commonly present in the flora of human epithelia and mucosal membranes. Over the last two decades, similarly to other CNS species, S. warneri has been reported as a new emerging pathogen, capable of causing serious infections usually in association with the presence of implant materials, but, at times, even in the absence of a foreign body and in patients considered immunocompetent. At present, there is still a lack of scientific data on the pathogenesis and epidemiology of this species. The present study investigated a collection of 26 clinical isolates derived from orthopedic infections, some associated with implant materials and others not. Automated ribotyping showed the existence of 5 distinct ribogroups. Except for the least numerous ribogroup consisting of a single isolate, all other ribogroups included at least one strain obtained from an infection not associated with implant materials, suggesting that putative virulence factors necessary for infections even in the absence of a foreign body could be transversal to most ribogroup categories. Orthopedic infections were found to involve S. warneri strains with low antibiotic resistance potential, differing in this respect from the strains isolated at neonatal intensive care units, where this species has been described to figure among the principal causative agents and exhibit an alarming profile of antibiotic resistance.