EEG analysis reveals widespread directed functional interactions related to a painful cutaneous laser stimulus.
EEG analysis reveals widespread directed functional interactions related to a painful cutaneous laser stimulus.
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脑电图分析揭示了与疼痛的皮肤激光刺激相关的广泛的定向功能相互作用。
DOI：
10.1152/jn.00246.2013
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发表时间：
2013
影响因子：
2.5
通讯作者：
Lenz,FA
中科院分区：
文献类型：
--
作者：
Markman,T;Liu,CC;Chien,JH;Crone,NE;Zhang,J;Lenz,FA
在对疼痛的皮肤激光刺激的注意过程中，事件相关因果关系（ERC）在硬膜下电极直接植入治疗癫痫的皮质模块的记录中被检测到。然而，这些研究提供了有限的模块样本，并没有检查与非疼痛刺激的相互作用作为对照。我们现在对头皮脑电图进行采样，以验证对激光刺激的注意与刺激后ERC相互作用有关的假设，这种相互作用不同于对非疼痛刺激的注意。受试者参加（计数）疼痛的激光刺激（激光注意力任务）或非疼痛的皮肤电刺激（激光分心任务）。这两种刺激以随机顺序呈现在一个单一的序列中。调整两种刺激的强度，使其在同一皮肤区域产生相似的基线显著性和感觉。结果表明，刺激后ERC相互作用的脑电通道在激光刺激和电刺激期间始终不同。激光注意任务的刺激后ERC相互作用与激光分心任务不同。此外，在这两个任务中，头皮脑电额叶通道起驱动作用，而顶叶颞叶通道起接收作用，尽管这并不能证明这些通道是连接的。在激光注意和分散任务中发现大量ERC相互作用的位点（关键位点）位于Cz， Pz和C3。刺激导致这些疼痛相关的相互作用部位的破坏可能产生急性疼痛的镇痛。
During attention to a painful cutaneous laser stimulus, event-related causality (ERC) has been detected in recordings from subdural electrodes implanted directly over cortical modules for the treatment of epilepsy. However, these studies afforded limited sampling of modules and did not examine interactions with a nonpainful stimulus as a control. We now sample scalp EEG to test the hypothesis that attention to the laser stimulus is associated with poststimulus ERC interactions that are different from those with attention to a nonpainful stimulus. Subjects attended to (counted) either a painful laser stimulus (laser attention task) or a nonpainful electrical cutaneous stimulus that produced distraction from the laser (laser distraction task). Both of these stimuli were presented in random order in a single train. The intensities of both stimuli were adjusted to produce similar baseline salience and sensations in the same cutaneous territory. The results demonstrated that EEG channels with poststimulus ERC interactions were consistently different during the laser stimulus versus the electric stimulus. Poststimulus ERC interactions for the laser attention task were different from the laser distraction task. Furthermore, scalp EEG frontal channels play a driver role while parietal temporal channels play a receiver role during both tasks, although this does not prove that these channels are connected. Sites at which large numbers of ERC interactions were found for both laser attention and distraction tasks (critical sites) were located at Cz, Pz, and C3. Stimulation leading to disruption of sites of these pain-related interactions may produce analgesia for acute pain.