Usefulness of a New Therapy Using Rebamipide Eyedrops in Patients with VKC/AKC Refractory to Conventional Anti-Allergic Treatments
Usefulness of a New Therapy Using Rebamipide Eyedrops in Patients with VKC/AKC Refractory to Conventional Anti-Allergic Treatments
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DOI：
10.2332/allergolint.13-oa-0605
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发表时间：
2014-03-01
影响因子：
6.8
通讯作者：
Kinoshita, Shigeru
中科院分区：
文献类型：
--
作者：
Ueta, Mayumi;Sotozono, Chie;Kinoshita, Shigeru
背景：瑞巴匹特是一种胃保护药物，已有报道可抑制胃粘膜炎症。在日本，瑞巴比特眼药水最近已被批准用于治疗干眼症。一些过敏性结膜疾病患者，如春季角结膜炎(VKC)或特应性角结膜炎(AKC)，表现为干眼症，但泪液破裂时间减少。我们报告了对抗过敏治疗无效的VKC/AKC患者，他们在常规抗过敏治疗的基础上加用抗过敏和/或免疫抑制/类固醇滴眼液。方法：4例过敏性结膜病合并巨大乳头(VKC或AKC)患者，每天滴注瑞巴匹特滴眼液3~4次，疗程不同。所有人都有干眼症，泪水破裂时间减少。我们使用Image J软件评估了他们的巨大乳头的大小的变化。结果：我们观察到所有4例患者的巨大乳头的衰减。在2名病情严重的患者中，尽管使用了他克莫司和类固醇，他们的巨大乳头还是变大了，瑞巴匹特的加入有助于其减弱。在2例轻度疾病患者中，服用抗过敏药物后，巨大乳头变大或保持不变；加入瑞巴比特滴眼液后，其巨大乳头也变小。结论：瑞巴匹特滴眼液可使过敏性结膜疾病患者的巨大乳头变小，这些滴眼液不仅可用于干眼，还可用于过敏性结膜疾病。
Background: Rebamipide, a gastroprotective drug, has been reported to suppress gastric mucosal inflammation. In Japan, rebamipide eyedrops have recently been approved for the treatment of dry eye disease. Some patients with allergic conjunctival diseases such as vernal keratoconjunctivitis (VKC) or atopic keratoconjunctivitis (AKC) manifest dry eye with decreased tear break-up time only. We report patients with VKC/AKC refractory to anti-allergic treatments who responded to the combination of rebamipide eyedrops and conventional anti-allergic treatments with anti-allergic- and/or immunosuppressive/steroid eyedrops.Methods: Four patients with allergic conjunctival diseases with giant papillae (VKC or AKC) instilled rebamipide eyedrops three or four times a day for varying periods. All had dry eye with decreased tear break-up time. We evaluated changes in the size of their giant papillae using Image J software.Results: We observed attenuation of the giant papillae in all 4 patients. In 2 patients with severe disease, whose giant papillae had become larger despite the administration of tacrolimus and steroids, the addition of rebamipide contributed to their attenuation. In 2 patients with mild disease, the giant papillae had become larger or remained the same size despite the administration of anti-allergy drugs; the addition of rebamipide eyedrops also resulted in the attenuation of their giant papillae.Conclusions: Our findings suggest that rebamipide eyedrops might attenuate giant papillae in patients with allergic conjunctival diseases and that these eyedrops may be useful for the treatment of not only dry eye but also of allergic conjunctival diseases.