Longxuetongluo Capsule Improves Erythrocyte Function against Lipid Peroxidation and Abnormal Hemorheological Parameters in High Fat Diet-Induced ApoE-/- Mice.
Longxuetongluo Capsule Improves Erythrocyte Function against Lipid Peroxidation and Abnormal Hemorheological Parameters in High Fat Diet-Induced ApoE-/- Mice.
复制标题
龙血通络胶囊改善高脂饮食诱导的 ApoE-/- 小鼠红细胞抗脂质过氧化和血液流变学参数异常的功能。
DOI：
10.1155/2016/2603219
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发表时间：
2016
影响因子：
--
通讯作者：
Tu P
中科院分区：
文献类型：
--
作者：
Zheng J;Liu B;Lun Q;Yao W;Zhao Y;Xiao W;Huang W;Wang Y;Li J;Tu P
中国龙的血，红色树脂的龙血树，著名的传统药物之一，已被用来促进血液循环和分散血瘀了几千年。酚类化合物被认为是其主要的生物活性。本研究将龙血竭总酚类化合物制成胶囊（龙血通络胶囊，LTC），用高脂饮食（HFD）诱导的ApoE−/−小鼠，观察其对血液流变学异常的影响。与模型组相比，LTC能快速降低ApoE−/−小鼠全血粘度（WBV），改善红细胞功能，使异常的血液流变学指标得到恢复。总之，LTC可以通过减少HFD诱导的ApoE−/−小鼠血浆和红细胞膜上的脂质过氧化作用来改善红细胞变形性和渗透脆性，这支持了中国龙血竭作为改善高胆固醇血症血液微循环的有效药物的传统用途。
Chinese dragon's blood, the red resin of Dracaena cochinchinensis, one of the renowned traditional medicines, has been used to facilitate blood circulation and disperse blood stasis for thousands of years. Phenolic compounds are considered to be responsible for its main biological activities. In this study, total phenolic compounds of Chinese dragon's blood were made into capsule (Longxuetongluo Capsule, LTC) and their effects on the abnormal hemorheological properties were examined by high fat diet (HFD) induced ApoE−/− mice. Compared to the model group, LTC recovered the abnormal hemorheological parameters in HFD-induced ApoE−/− mice by reducing whole blood viscosity (WBV) at high rate and improving erythrocyte function. In conclusion, LTC could ameliorate erythrocyte deformability and osmotic fragility through the reduction of lipid peroxidation on plasma and erythrocyte membranes in HFD-induced ApoE−/− mice, which supported the traditional uses of Chinese dragon's blood as an effective agent for improving blood microcirculation in hypercholesterolemia.