Spatiotemporal properties of neuron response suppression in owl monkey primary somatosensory cortex when stimuli are presented to both hands.
Spatiotemporal properties of neuron response suppression in owl monkey primary somatosensory cortex when stimuli are presented to both hands.
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DOI：
10.1523/jneurosci.4310-10.2011
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发表时间：
2011-03-09
期刊：
影响因子：
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通讯作者：
Kaas JH
中科院分区：
文献类型：
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作者：
Reed JL;Qi HX;Kaas JH
尽管缺乏同侧感受野（RF）的神经元在手的初级躯体感觉皮层3b区的代表，半球间的相互作用已被报道在不同程度上。我们调查了这些相互作用的时空特性，以确定：响应类型;刺激之间的时间，以引起最强的双手互动;地形分布的影响;和它们的依赖刺激位置的相似性，在两个手。我们分析了反应的幅度和lavernity的单神经元和多神经元簇记录从100个电极阵列植入在一个半球的每两个麻醉猫头鹰猴。皮肤压痕同时和异步地在镜像位置（每只手上的匹配部位）和非镜像位置传递到双手。由于同时记录多个神经元，对侧手的刺激可能在任何给定神经元的经典RF之内或之外。对于大多数神经元来说，同侧手的刺激会抑制对侧手刺激的反应。当同侧刺激出现在对侧刺激开始前100 ms时，抑制最大（P < 0.0005）。测试的最长刺激起始延迟（500 ms）允许对侧反应恢复到对照水平（P = 0.428）。镜像手指上的刺激与非镜像位置上的刺激没有差异（P = 1.000）。这些结果表明，半球间的相互作用是常见的3b区，有点地形扩散，最大的抑制同侧刺激之前，对侧刺激。我们的研究结果指出，在人类心理物理研究双手刺激的“干扰”效应的神经生理学基础。
Despite the lack of ipsilateral receptive fields (RFs) for neurons in the hand representation of area 3b of primary somatosensory cortex, interhemispheric interactions have been reported to varying degrees. We investigated spatiotemporal properties of these interactions to determine: response types; timing between stimuli to evoke the strongest bimanual interactions; topographical distribution of effects; and their dependence on similarity of stimulus locations on the two hands. We analyzed response magnitudes and latencies of single neurons and multi-neuron clusters recorded from 100-electrode arrays implanted in one hemisphere of each of two anesthetized owl monkeys. Skin indentations were delivered to the two hands simultaneously and asynchronously at mirror locations (matched sites on each hand) and non-mirror locations. Since multiple neurons were recorded simultaneously, stimuli on the contralateral hand could be within or outside of the classical RFs of any given neuron. For most neurons, stimulation on the ipsilateral hand suppressed responses to stimuli on the contralateral hand. Maximum suppression occurred when the ipsilateral stimulus was presented 100ms before the contralateral stimulus onset (P < 0.0005). The longest stimulus onset delay tested (500ms) allowed contralateral responses to recover to control levels (P = 0.428). Stimulation on mirror digits did not differ from stimulation on non-mirror locations (P = 1.000). These results indicate that interhemispheric interactions are common in area 3b, somewhat topographically diffuse, and maximal when the suppressing ipsilateral stimulus preceded the contralateral stimulus. Our findings point to a neurophysiological basis for “interference” effects found in human psychophysical studies of bimanual stimulation.