The role of miRNA and lncRNA in gastric cancer.
The role of miRNA and lncRNA in gastric cancer.
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DOI：
10.18632/oncotarget.19197
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发表时间：
2017-10-06
期刊：
影响因子：
--
通讯作者：
Wang RL
中科院分区：
文献类型：
--
作者：
Hao NB;He YF;Li XQ;Wang K;Wang RL
胃癌是世界上最常见的癌症之一，也是死亡率最高的癌症。胃癌发生发展的机制值得探讨。越来越多的研究发现，包括miRNA和lncRNA在内的非编码rna在胃癌的进展中发挥着重要作用。本文就异位miRNA在胃癌增殖、生长、迁移、侵袭和凋亡中的作用进行综述。同时，异常表达的miRNA作为胃癌诊断和治疗的潜在生物标志物也受到了广泛关注。在过去的十年中，lncRNA被认为在转录和转录后水平调控胃癌的进展。在转录水平上，lncRNA通过改变染色质修饰和mRNA稳定来调控mRNA和miRNA的表达，从而诱导胃癌的进展。此外，lncRNA在转录后水平通过与miRNA完全结合产生ceRNA或促进蛋白稳定来调控胃癌的进展。在胃癌中对miRNA和lncRNA的进一步关注，可以为癌症的发生机制提供新的认识，并可能作为新的抗癌靶点。
Gastric cancer is one of the most common cancers and has the highest mortality rate worldwide. It is worthwhile to explore the mechanism of gastric cancer progression. An increasing number of studies have found that non-coding RNAs including miRNA and lncRNA play important roles in gastric cancer progression. This review summarized the role of ectopic miRNA in gastric cancer proliferation, growth, migration, invasion and apoptosis. Meantime, aberrantly expressed miRNA also received a great deal of attention as potential biomarker for gastric cancer diagnosis and therapy. Over the last decade, lncRNA was considered to regulate gastric cancer progression at the transcript and post-transcript level. At the transcript level, lncRNA induced gastric cancer progression by changing chromatin modification and mRNA stabilization to regulate mRNA and miRNA expression. Furthermore, lncRNA regulated gastric cancer progression by completely combining with miRNA to produce ceRNA or promote protein stabilization at the post-transcript level. Greater attention of miRNA and lncRNA in gastric cancer can provide new insight of mechanism of cancer development and may be acted as a new anticancer target.
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