Sensory modalities conveyed in the hindlimb somatic afferent input to nucleus tractus solitarius.
Sensory modalities conveyed in the hindlimb somatic afferent input to nucleus tractus solitarius.
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DOI：
10.1152/jappl.2000.88.6.2062
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发表时间：
2000-06
影响因子：
3.3
通讯作者：
G. Toney;S. Mifflin
中科院分区：
文献类型：
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作者：
G. Toney;S. Mifflin
为了确定后肢躯体传入输入所传递的躯体感觉模式，在电刺激对侧坐骨神经或支配后肢的L（6）脊神经后，记录麻醉大鼠孤束核中神经元的放电。8个细胞中有7个的放电增加（P <60%）（11/18）。静态（10- 30-s）MC显著增加4个细胞的放电（P < 0.05），其中2个细胞对节律性MC也有反应。节律性和持续性肌肉牵拉可增加8个神经元中3个的放电（P < 0.05）。这些数据表明，孤束核神经元接收输入的低和高阈值皮肤mechanoreceptors，响应辣椒素传递到后肢动脉供应，缺乏热敏感性，并响应激活骨骼肌的mechanosensitive以及metabosensitive结束。
To determine the somatic sensory modalities conveyed by hindlimb somatic afferent inputs, the discharge of neurons in the nucleus tractus solitarius was recorded in anesthetized rats after electrical stimulation of either the contralateral sciatic nerve or L(6) spinal nerve, which innervates the hindlimb. The discharge of seven of eight cells was increased (P 60% of neurons tested (11 of 18). Static (10- to 30-s) MC significantly (P < 0.05) increased discharge in four cells, two of which were also responsive to rhythmic MC. Rhythmic and sustained muscle stretch increased discharge (P < 0.05) in three of eight neurons tested. These data indicate that nucleus tractus solitarius neurons receive input from low- and high-threshold cutaneous mechanoreceptors, respond to capsaicin delivered into the hindlimb arterial supply, lack thermal sensitivity, and respond to activation of mechanosensitive as well as metabosensitive endings in skeletal muscle.