Ce6/Mn2+-chelated polydopamine@black-TiO2 nanoprobes for enhanced synergistic phototherapy and magnetic resonance imaging in 4T1 breast cancer
Ce6/Mn2+-chelated polydopamine@black-TiO2 nanoprobes for enhanced synergistic phototherapy and magnetic resonance imaging in 4T1 breast cancer
复制标题
Ce6/Mn2 螯合聚多巴胺@black-TiO2 纳米探针用于增强 4T1 乳腺癌协同光疗和磁共振成像
DOI：
10.1039/c9nr09236f
复制
发表时间：
2020-01-21
期刊：
影响因子：
6.7
通讯作者：
Zeng, Leyong
中科院分区：
文献类型：
--
作者：
Gao, Yang;Zhang, Luyun;Zeng, Leyong
黑色二氧化钛（TiO 2）纳米粒子由于其在光热治疗（PTT）中的应用而引起了极大的关注。然而，单模光疗存在复发的风险，并且通常为提高PTT性能而施加的高剂量激光会给安全性带来潜在威胁。在这里，聚多巴胺（PDA）涂层的黑色二氧化钛合成了具有核-壳结构的（b-P25@PDA）纳米粒子用于增强PTT;然后，协同光疗纳米探针（b-P25@PDA-Ce 6（Mn））通过偶联二氢卟酚e6（Ce 6）和螯合Mn 2+构建，用于同时光动力学疗法（PDT）/PTT和磁共振（MR）成像，其中使用了低剂量激光，并实现了高效和高安全性的成像引导光疗。所制备的纳米探针显示出高的光热转换效率（32.12%），高活性氧的产生和良好的MR成像。在4 T1荷瘤裸鼠模型中，PDT/PTT与低剂量激光的组合下肿瘤完全消失，但仅被单独的PDT和单独的PTT部分抑制。目前的工作开发了一种多功能的黑色二氧化钛基纳米探针，用于增强协同PDT/PTT和MR成像，这将是重要的安全和有效的可视化治疗诊断癌症。
Black titanium dioxide (TiO2) nanoparticles have attracted great attention due to their application in photothermal therapy (PTT). However, single-mode phototherapy has the risk of recurrence, and the high-dose laser usually imposed to improve the PTT performance can bring a potential threat to security. Here, polydopamine (PDA)-coated black TiO2 (b-P25@PDA) nanoparticles with a core-shell structure were synthesized for enhanced PTT; then, synergistic phototherapy nanoprobes (b-P25@PDA-Ce6 (Mn)) were constructed by coupling chlorin e6 (Ce6) and chelating Mn2+ for simultaneous photodynamic therapy (PDT)/PTT and magnetic resonance (MR) imaging, in which a low-dose laser was used and imaging-guided phototherapy with high efficiency and high safety was achieved. The prepared nanoprobes showed high photothermal conversion efficiency (32.12%), high reactive oxygen generation and excellent MR imaging. In the 4T1 tumor-bearing nude mouse model, the tumors completely disappeared under the combination of PDT/PTT with a low-dose laser but were only partially inhibited by single PDT and single PTT. The current work developed a multifunctional black TiO2-based nanoprobe for enhanced synergistic PDT/PTT and MR imaging, which will be important for the safe and efficient visualized theranostics of cancers.