Role of Epigenetics in Uveal Melanoma.
Role of Epigenetics in Uveal Melanoma.
复制标题
表观遗传学在葡萄膜黑色素瘤中的作用
DOI：
10.7150/ijbs.18331
复制
发表时间：
2017
影响因子：
9.2
通讯作者：
Ge S
中科院分区：
文献类型：
--
作者：
Li Y;Jia R;Ge S
葡萄膜黑色素瘤(UM)是一种严重的人类恶性肿瘤，死亡率高，需要继续研究新的和替代的预防和治疗形式。新兴的表观遗传学领域正开始开启一个当代方法的时代，以降低UM的风险并改善临床治疗。表观遗传变化在癌症中的患病率很高，本质上是可逆的，即使在无突变的细胞中也可能导致癌症特征。本文着重阐述了表观遗传失调在UM发生、发展和转移中的主要机制，包括microRNA表达、基因高甲基化和组蛋白修饰。表观遗传药物已被证明在许多其他癌症细胞系和动物模型中增强肿瘤抑制基因的表达和药物敏感性。增加对UM表观遗传机制的了解将对设计更有效的表观遗传药物具有非常重要的价值，当这些药物与传统疗法结合使用时，可能会改善治疗结果。
Uveal melanoma (UM) is a severe human malignancy with a high mortality rate that demands continued research into new and alternative forms of prevention and treatment. The emerging field of epigenetics is beginning to unfold an era of contemporary approaches to reducing the risk and improving the clinical treatment of UM. Epigenetic changes have a high prevalence rate in cancer, are reversible in nature, and can lead to cancer characteristics even in mutation-free cells. The information contained in this review highlights and expands on the main mechanisms of epigenetic dysregulation in UM tumorigenesis, progression and metastasis, including microRNA expression, hypermethylation of genes and histone modification. Epigenetic drugs have been shown to enhance tumor suppressor gene expression and drug sensitivity in many other cancer cell lines and animal models. An increased understanding of epigenetic mechanisms in UM will be invaluable in the design of more potent epigenetic drugs, which when used in combination with traditional therapies, may permit improved therapeutic outcomes.