Autoantibody formation in burn patients after inhibition of suppressor T cell activity with polymyxin B.
Autoantibody formation in burn patients after inhibition of suppressor T cell activity with polymyxin B.
复制标题
烧伤患者用多粘菌素 B 抑制抑制性 T 细胞活性后形成自身抗体。
DOI：
10.1097/00004630-198905000-00005
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Munster,AM
中科院分区：
文献类型：
--
作者：
Moran,KT;Anholt,GT;O'Reilly,TJ;Thupari,JN;Munster,AM
After thermal injury, treatment with polymyxin B blocks suppressor T cell activity by uncoupling endotoxin-mediated T cell activation, but the effect on autoantibody formation is unknown. We examined the presence of antinuclear antibodies to native DNA; to soluble antigens Ro/SSA, La/SSB, Sm, nRNP; and to antiepithelial antibodies in 12 burn patients before and after treatment with polymyxin B and in 24 samples from control burn patients. Low titer antinuclear antibody activity was detected in 25% of pretreatment and 78% of posttreatment samples (p<0.01) and in 16.7% of control patients. One polymyxin B—treated patient had a significant antinuclear antibody titer both before and after treatment. Antiepithelial antibodies were detected in 16.7% of early polymyxin B— treated samples and 11.1% of late samples (j><0.05) but were also present in 20.8% of controls. Antibodies to native DNA, Ro/SSA, La/SSB, Sm, and nRNP were not detected in any sera. (J BURN CARE REHABDL 1989;10:213-5)
