The discovery of Arylex™ active and Rinskor™ active: Two novel auxin herbicides
The discovery of Arylex™ active and Rinskor™ active: Two novel auxin herbicides
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DOI：
10.1016/j.bmc.2015.08.011
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发表时间：
2016-02-01
影响因子：
3.5
通讯作者：
Yerkes, Carla N.
中科院分区：
文献类型：
--
作者：
Epp, Jeffrey B.;Alexander, Anita L.;Yerkes, Carla N.
自20世纪40年代以来，人们已经发现了多种具有重要商业价值的生长素除草剂，包括芳氧基乙酸酯(2，4-D、MCPA、敌敌畏、甲氰菊酯、三氯吡啶和氟草胺)、苯甲酸酯(敌草畏)、喹啉-2-羧酸酯(二氯喹啉酸和喹麦酸)、嘧啶-4-羧酸酯(氨基环丙草胺)和吡啶-2-羧酸酯(吡氯丙烯、氯丙草胺和氨基丙草胺)。在过去的10年里，陶氏农业科学公司发现了两种新型的吡啶-2-羧酸盐(或吡啶甲酸酯)除草剂。本文将描述导致发现6-芳基-吡啶甲酸酯除草剂Arylex(TM)活性(2005)和Rinskor(TM)活性(2010)的构效关系研究。虽然Arylex主要用于谷类作物，Rinskor仍在开发中，主要用于水稻作物，但这两种除草剂也将用于其他作物。(C)2015爱思唯尔有限公司。保留所有权利。
Multiple classes of commercially important auxin herbicides have been discovered since the 1940s including the aryloxyacetates (2,4-D, MCPA, dichlorprop, mecoprop, triclopyr, and fluroxypyr), the benzoates (dicamba), the quinoline-2-carboxylates (quinclorac and quinmerac), the pyrimidine-4-carboxylates (aminocyclopyrachlor), and the pyridine-2-carboxylates (picloram, clopyralid, and aminopyralid). In the last 10 years, two novel pyridine-2-carboxylate (or picolinate) herbicides were discovered at Dow AgroSciences. This paper will describe the structure activity relationship study that led to the discovery of the 6-aryl-picolinate herbicides Arylex (TM) active (2005) and Rinskor (TM) active (2010). While Arylex was developed primarily for use in cereal crops and Rinskor is still in development primarily for use in rice crops, both herbicides will also be utilized in additional crops. (C) 2015 Elsevier Ltd. All rights reserved.