Rapid Eye Movement Sleep Percentage in Children With Autism Compared With Children With Developmental Delay and Typical Development
Rapid Eye Movement Sleep Percentage in Children With Autism Compared With Children With Developmental Delay and Typical Development
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DOI：
10.1001/archpediatrics.2010.202
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发表时间：
2010-11-01
影响因子：
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通讯作者：
Swedo, Susan
中科院分区：
文献类型：
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作者：
Buckley, Ashura Williams;Rodriguez, Alcibiades J.;Swedo, Susan
目的：比较 3 个队列之间的客观多导睡眠图参数：自闭症儿童、典型发育和非自闭症发育迟缓。设计：由委员会认证的睡眠医学专家根据美国睡眠医学会标准对隔夜多导睡眠图记录的睡眠结构进行评分，该专家对 2006 年 7 月至 2009 年 9 月期间收集的研究不知情。地点：受试者在美国国立卫生研究院临床研究中心的儿科病房进行评估。参与者：前 60 名连续的自闭症儿童，其中 15 名发育正常，13 名发育迟缓与自闭症组的非语言智商相匹配，年龄范围为 2 至 13 岁，选择时不考虑是否存在睡眠问题行为。主要结果指标：总睡眠时间、非快速眼动 (REM) 和 REM 睡眠的潜伏期，以及第一阶段和第二阶段睡眠、慢波睡眠和睡眠的总睡眠时间百分比。快速眼动睡眠。结果：典型组与发育迟缓组之间没有差异。自闭症儿童与普通儿童的比较显示，总睡眠时间更短 (P=.004)，慢波睡眠百分比更高 (P=.001)，快速眼动睡眠百分比更小（14.5% vs 22.6%；P
Objective: To compare objective polysomnographic parameters between 3 cohorts: children with autism, typical development, and developmental delay without autism.Design: Overnight polysomnographic recordings were scored for sleep architecture according to American Academy of Sleep Medicine criteria by a board-certified sleep medicine specialist blind to diagnosis for studies collected between July 2006 and September 2009.Setting: Subjects were evaluated in the pediatric ward in the Clinical Research Center of the National Institutes of Health.Participants: First 60 consecutive children with autism, 15 with typical development, and 13 with developmental delay matched for nonverbal IQ to the autism group, ranging in age from 2 to 13 years, selected without regard to the presence or absence of sleep problem behavior.Main Outcome Measures: Total sleep time, latencies to non-rapid eye movement (REM) and REM sleep, and percentages of total sleep time for stages 1 and 2 sleep, slow-wave sleep, and REM sleep.Results: There were no differences between the typical vs developmental delay groups. Comparison of children with autism vs typical children revealed shorter total sleep time (P=.004), greater slow-wave sleep percentage (P=.001), and much smaller REM sleep percentage (14.5% vs 22.6%; P