Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells.
Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells.
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DOI：
10.1038/ni.2309
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发表时间：
2012-05-27
影响因子：
30.5
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中科院分区：
文献类型：
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尽管在淋巴结的T细胞区内发生表达CCR 7的携带抗原的树突状细胞（DC）和CCR 7+幼稚T细胞之间的同源相遇，但尚不清楚DC和T细胞在T细胞区内的共定位是否是效应子产生的必需条件。在这里，我们表明，线虫感染后，抗原携带的DC和CD 4 + T细胞上调CXCR 5和共定位在CXCL 13，B细胞和T区外的光毒素依赖的方式。重要的是，表达光毒素的B细胞、表达CXCL 13和CXCR 5的DC和T细胞对于产生白细胞介素4（IL-4）的TH 2细胞的发育也是必需的，这表明TH 2分化可以在T细胞区之外启动。
Although cognate encounters between CCR7-expressing antigen-bearing dendritic cells (DCs) and CCR7+ naïve T cells take place within the T cell zone of lymph nodes, it is unknown whether co-localization of the DCs and T cells within the T cell area is obligate for effector generation. Here, we show that, following nematode infection, antigen-bearing DCs and CD4+ T cells upregulate CXCR5 and co-localize in a CXCL13, B cell and lymphotoxin-dependent fashion outside of the T zone. Importantly, lymphotoxin-expressing B cells, CXCL13 and CXCR5-expressing DCs and T cells are also necessary for development of interleukin 4 (IL-4) producing TH2 cells, suggesting that TH2 differentiation can initiate outside of the T cell zone.