Reflections on type I photodynamic damage.
Reflections on type I photodynamic damage.
复制标题
对 I 型光动力损伤的思考。
DOI：
10.1016/1011-1344(93)80080-s
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Rodgers,MA
中科院分区：
文献类型：
--
作者：
Rodgers,MA
Recently, views have been expressed in this journal [l] and in Photochemistry and Photobiology [2] that have drawn attention to the two possible mechanisms (types I and II) by which photodynamic damage is thought to occur. Notwithstanding the contrasting viewpoints of Foote [2] and Vidbczy [l], the basic difference between the mechanisms seems to be in the nature of the primary dark reaction of the photosensitizer excited state. This is either an electron transfer (LT) process or an energy transfer (NT) process. The energy recipient in the latter is fairly safely identified as 02, it being the only biological molecule having an electronic state (‘A,) low enough in energy to behave as an acceptor when the donors are T1 states of porphyrins, xanthenes and phthalocyanines. Coreactants in electron transfer reactions are less readily identified, and probably for this reason the focus of photodynamic research has been on singlet oxygen pathways. However, given some reasonable requisite assumptions, electron transfer targets can be identified, and useful experimental strategies can be formulated. In the following, the principal targets for LT-induced photodynamic damage are identified as the amino acids cysteine (Cys), methionine (Met), tryptophan(Trp) and tyrosine
