Tissue-specific response to interstitial angiotensin II in humans
Tissue-specific response to interstitial angiotensin II in humans
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DOI：
10.1161/01.hyp.0000042665.85720.a0
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发表时间：
2003-01-01
期刊：
影响因子：
8.3
通讯作者：
Klaus, S
中科院分区：
文献类型：
--
作者：
Boschmann, M;Jordan, J;Klaus, S
Angiotensin II is synthesized locally in various tissues; however, the role of interstitial angiotensin II in the regulation of regional. metabolism and tissue perfusion is not clear. We characterized the effect of interstially applied angiotensin II in skeletal muscle and subcutaneous adipose tissue of young, normal-weight, healthy subjects by using the microdialysis technique. Furthermore, we tested the hypothesis that the effect of interstitial angiotensin II is modulated by nitric oxide. Tissues were perfused with 0.01, 0.1, and 1 mumol/L angiotensin II in the presence of the L- or D-isomer of N-G-nitro-arginine-methyl ester (L- or D-NAME), the effective and noneffective isomer, respectively, for blocking nitric oxide synthase. Dialysate ethanol, glycerol, glucose, lactate, and pyruvate concentrations were measured to assess changes in blood flow (ethanol dilution technique), lipolysis, and glycolysis, respectively. Baseline blood flow and dialysate concentrations of the metabolites were similar with L- and D-NAME in both tissues. Blood flow and dialysate glucose and lactate did not change significantly in both tissues during perfusion with angiotensin II. Dialysate glycerol dose-dependently increased in adipose tissue (P
