c-Myc as a therapeutic target in cancer.
c-Myc as a therapeutic target in cancer.
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DOI：
10.1586/14737140.4.2.289
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发表时间：
2004-04-01
影响因子：
3.3
通讯作者：
Prochownik, Edward V
中科院分区：
文献类型：
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作者：
Prochownik, Edward V
c-Myc在人类癌症中经常失调。c-Myc癌蛋白是一种转录因子，其许多靶基因编码启动和维持转化状态的蛋白质。c-Myc也是一个动态网络的一部分，该网络的成员选择性地相互作用，并与各种转录辅助调节因子和组蛋白修饰酶相互作用。这一知识突出了几个可能受到攻击的要点。本文综述了c-Myc基因的转录、翻译、与其他myc网络成员的相互作用、DNA结合和转录激活等方面的研究进展。c-Myc的抑制可以通过许多这些方法来实现;然而，临床疗效可能需要在几个水平上进行干预，可能与传统的化疗药物或靶向其他癌蛋白的药物联合使用。
c-Myc is frequently deregulated in human cancers. The c-Myc oncoprotein is a transcription factor, with many of its target genes encoding proteins that initiate and maintain the transformed state. c-Myc is also part of a dynamic network whose members interact selectively with one another and with various transcriptional coregulators and histone-modifying enzymes. This knowledge highlights several points that might be amenable to attack. This review summarizes progress in controlling the extent of c-Myc transcription, translation, interaction with other myc network members, DNA binding and transcriptional activation. Inhibition of c-Myc can be achieved with many of these approaches; however, clinical efficacy will likely require intervention at several levels, perhaps in combination with traditional chemotherapeutic drugs or agents that target other oncoproteins.