Meta-analysis of measures of sexual activity and prostate cancer
Meta-analysis of measures of sexual activity and prostate cancer
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DOI：
10.1097/00001648-200201000-00012
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发表时间：
2002-01-01
期刊：
影响因子：
5.4
通讯作者：
Dawson, DV
中科院分区：
文献类型：
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作者：
Dennis, LK;Dawson, DV
我们对前列腺癌和性活动之间的关联进行了荟萃分析。这些数据表明，有性传播感染史的男性患前列腺癌的相对风险（RR）升高。随机和固定效应模型均观察到这一点（RR = 1.4; 95% CI = 1.2-1.7; N = 17项研究;异质性P = 0.14），尤其是梅毒（RR = 2.3; 95% CI = 1.3-3.9; N = 6;异质性P = 0.47）。前列腺癌的风险也与性活动频率增加有关（RR = 1.2，每周增加3次; 95% CI = 1.1-1.3; N = 12）。然而，这些研究是异质性的（P <0.001），性伴侣数量的增加也与前列腺癌有关（RR = 1.2，增加20名伴侣; 95% CI = 1.1-1.3; N = 16;异质性P = 0.11）。这些数据不支持与多次婚姻，首次性交年龄或初婚年龄的关联。这些结果表明前列腺癌和性传播感染之间存在关联，表明感染可能是前列腺癌发展的一种机制。性活动频率与前列腺癌相关的机制尚不清楚。
We conducted a meta-analysis of the association between prostate cancer and aspects of sexual activity. The data Suggest an elevated relative risk (RR) of prostate cancer among men with a history of sexually transmitted infections. This was observed with both random and fixed-effects models (RR = 1.4; 95% CI = 1.2-1.7; N = 17 studies; heterogeneity P = 0.14), especially for syphilis (RR = 2.3; 95% CI = 1.3-3.9; N = 6; heterogeneity P = 0.47). Risk of prostate cancer is also associated with increasing frequency of sexual activity (RR = 1.2 for an increase of three times per week; 95% CI = 1.1-1.3; N = 12). However, these studies are heterogeneous (P < 0,001), Increasing number of sexual partners Ls also associated With prostate cancer (RR = 1.2 for an increase of 20 partners; 95% CI = 1.1-1.3; N = 16; heterogeneity P = 0.11). The data do not support associations with multiple marriages, age at first intercourse, or age at first marriage. These results indicate an association between prostate cancer and sexually transmitted infections, suggesting that infections may represent one mechanism through which prostate cancer develops. The mechanism through which frequency of sexual activity may be related to prostate cancer is unclear.