Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking.
Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking.
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DOI：
10.4161/sgtp.29469
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Ory, Stephane
中科院分区：
文献类型：
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作者：
Croise, Pauline;Estay-Ahumada, Catherine;Ory, Stephane
Rho GTP酶是众所周知的肌动蛋白细胞骨架的调节剂，其通过结合和激活肌动蛋白成核剂起作用。因此，它们参与了许多基于肌动蛋白的过程，包括细胞迁移，细胞极性和膜运输。随着磷酸肌醇激酶和磷酸酶作为潜在结合伴侣或效应物的鉴定，Rho GTP酶似乎也参与磷酸肌醇代谢的调节。由于肌动蛋白动力学和磷酸肌醇周转影响细胞室之间的囊泡运输的效率和保真度，Rho GTP酶已成为膜运输的关键参与者。Rho GT3活性、肌动蛋白重塑和磷酸肌醇代谢需要在空间和时间上协调，以确保囊泡沿沿着膜运输途径的进展。虽然大多数分子途径仍不清楚，在这篇综述中，我们将强调最近的进展，在我们的理解，Rho依赖的信号通路如何组织肌动蛋白动力学和磷酸肌醇和磷酸肌醇可能提供负反馈Rho GTPases在胞吞，胞吐和细胞内室之间的膜交换。
Rho GTPases are well known regulators of the actin cytoskeleton that act by binding and activating actin nucleators. They are therefore involved in many actin-based processes, including cell migration, cell polarity, and membrane trafficking. With the identification of phosphoinositide kinases and phosphatases as potential binding partners or effectors, Rho GTPases also appear to participate in the regulation of phosphoinositide metabolism. Since both actin dynamics and phosphoinositide turnover affect the efficiency and the fidelity of vesicle transport between cell compartments, Rho GTPases have emerged as critical players in membrane trafficking. Rho GTPase activity, actin remodeling, and phosphoinositide metabolism need to be coordinated in both space and time to ensure the progression of vesicles along membrane trafficking pathways. Although most molecular pathways are still unclear, in this review, we will highlight recent advances made in our understanding of how Rho-dependent signaling pathways organize actin dynamics and phosphoinositides and how phosphoinositides potentially provide negative feedback to Rho GTPases during endocytosis, exocytosis and membrane exchange between intracellular compartments.