Clinically Deployable Kinesia™ Technology for Automated Tremor Assessment
Clinically Deployable Kinesia™ Technology for Automated Tremor Assessment
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DOI：
10.1002/mds.22445
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发表时间：
2009-04-15
影响因子：
8.6
通讯作者：
Heldman, Dustin A.
中科院分区：
文献类型：
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作者：
Giuffrida, Joseph P.;Riley, David E.;Heldman, Dustin A.
其目的是设计、构建和评估Kinesia（TM），一种用于自动评估帕金森病（PD）震颤的无线系统。目前评估PD的标准是统一帕金森病评定量表（Unified Parkinson's Disease Rating Scale，简称PDRS）。通常在办公室访问期间完成的定性排名系统。Kinesia将加速度计和陀螺仪集成在一个紧凑的患者佩戴装置中，以捕获运动学运动障碍特征。客观地量化PD表现，提高时间分辨率，有助于评估治疗方案的疗效，改善患者管理。在这项研究中，PD受试者在佩戴Kinesia时进行了震颤亚组测试。对定量运动学特征进行处理，并与静息震颤（r（2）= 0.89）、姿势性震颤（r（2）= 0.90）的临床评分高度相关。运动性震颤（r（2）= 0.69）。定量特征被用于开发一个数学模型，该模型预测新数据的震颤严重程度评分，误差较低。最后，PD受试者表现出较高的临床接受度。(C)2009运动障碍协会
The objective was to design, build, and assess Kinesia (TM) a wireless system for automated assessment of Parkinson's disease (PD) tremor, The Current standard in evaluating PD is the Unified Parkinson's Disease Rating Scale (UPDRS). a qualitative ranking system typically completed during an office visit. Kinesia integrates accelerometers and gyroscopes in a compact patient-worn unit to capture kinematic movement disorder features. Objectively quantify PD manifestations with increased time resolution should aid in evaluating efficacy of treatment protocols and improve patient management. In this study, PD subjects performed the tremor subset of the UPDRS motor section while wearing Kinesia. Quantitative kinematic features were processed and highly correlated to clinician scores for rest tremor (r(2) = 0.89), postural tremor (r(2) = 0.90). and kinetic tremor (r(2) = 0.69). The quantitative features were used to develop a mathematical model that predicted tremor severity scores for new data with low errors. Finally, PD subjects indicated high clinical acceptance. (C) 2009 Movement Disorder Society