Performance of the xTAG® Gastrointestinal Pathogen Panel, a Multiplex Molecular Assay for Simultaneous Detection of Bacterial, Viral, and Parasitic Causes of Infectious Gastroenteritis
Performance of the xTAG® Gastrointestinal Pathogen Panel, a Multiplex Molecular Assay for Simultaneous Detection of Bacterial, Viral, and Parasitic Causes of Infectious Gastroenteritis
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DOI：
10.4014/jmb.1212.12042
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发表时间：
2013-07-01
影响因子：
2.8
通讯作者：
Topin, Francois
中科院分区：
文献类型：
--
作者：
Claas, Eric C.;Burnham, Carey-Ann D.;Topin, Francois
xTAG (R)胃肠道病原体小组（GPP）是一项针对15种胃肠道病原体的多重分子检测。该试验的敏感性和特异性在四个临床站点收集的901份儿童和成人患者粪便标本中进行了评估。采用常规方法和分子方法相结合的方法作为比较。15种病原菌中有12种具有敏感性，总体敏感性为94.3%。15个靶点的特异性为98.5%。在65%的标本中，医生未要求对已确定的病原体进行检测。同时检测这15种病原体可以为医生提供更全面的腹泻病病因评估。
The xTAG (R) Gastrointestinal Pathogen Panel (GPP) is a multiplexed molecular test for 15 gastrointestinal pathogens. The sensitivity and specificity of this test were assessed in 901 stool specimens collected from pediatric and adult patients at four clinical sites. A combination of conventional and molecular methods was used as comparator. Sensitivity could be determined for 12 of 15 pathogens and was 94.3% overall. The specificity across all 15 targets was 98.5%. Testing for the pathogen identified was not requested by the physician in 65% of specimens. The simultaneous detection of these 15 pathogens can provide physicians with a more comprehensive assessment of the etiology of diarrheal disease.