Vocal control area-related expression of neuropilin-1, plexin-A4, and the ligand semaphorin-3A has implications for the evolution of the avian vocal system
Vocal control area-related expression of neuropilin-1, plexin-A4, and the ligand semaphorin-3A has implications for the evolution of the avian vocal system
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DOI：
10.1111/j.1440-169x.2008.01080.x
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发表时间：
2009-01-01
影响因子：
2.5
通讯作者：
Okanoya, Kazuo
中科院分区：
文献类型：
--
作者：
Matsunaga, Eiji;Okanoya, Kazuo
鸟类发声系统是探索与行为多样性相关的神经回路进化的分子基础的良好模型。以前，我们进行了比较基因表达分析两个不同的家庭的声乐学习者，孟加拉雀（Lonchura striata var。一种鸣禽，虎皮鹦鹉（Melopsittacus undulatus），一种鹦鹉;和一种非学习者，鹌鹑（Coturnix coturnix），以确定各种轴突导向分子，如钙粘蛋白和神经纤毛蛋白-1作为发声控制区相关基因。在这里，我们继续这项研究，并检查在这些物种的神经纤毛蛋白和相关基因的表达更详细。我们发现，neuropilin-1和它的辅助受体，plexin-A4，在几个发声控制领域在孟加拉雀和虎皮鹦鹉的大脑中表达。此外，semaphorin-3A，神经纤毛蛋白-1的配体，表达没有检测到在这两个物种的发声控制区。此外，在鹌鹑脑中也有类似的基因表达。这些结果表明，在进化过程中的声音学习能力的收购semaphorin/neuropilin/plexin的组合的表达的变化的可能性。
The avian vocal system is a good model for exploring the molecular basis of neural circuit evolution related to behavioral diversity. Previously, we conducted a comparative gene expression analysis among two different families of vocal learner, the Bengalese finch (Lonchura striata var. domestica), a songbird, and the budgerigar (Melopsittacus undulatus), a parrot; and a non-learner, the quail (Coturnix coturnix), to identify various axon guidance molecules such as cadherin and neuropilin-1 as vocal control area-related genes. Here, we continue with this study and examine the expression of neuropilin and related genes in these species in more detail. We found that neuropilin-1 and its coreceptor, plexin-A4, were expressed in several vocal control areas in both Bengalese finch and budgerigar brains. In addition, semaphorin-3A, the ligand of neuropilin-1, expression was not detected in vocal control areas in both species. Furthermore, there was some similar gene expression in the quail brain. These results suggest the possibility that a change in the expression of a combination of semaphorin/neuropilin/plexin was involved in the acquisition of vocal learning ability during evolution.