Decidual luteotropin secretion and action: its role in pregnancy maintenance in the rat.
Decidual luteotropin secretion and action: its role in pregnancy maintenance in the rat.
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蜕膜促黄体素的分泌和作用：其在大鼠妊娠维持中的作用。
DOI：
10.1007/978-1-4684-5395-9_18
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发表时间：
1987
影响因子：
--
通讯作者：
Herz,Z
中科院分区：
文献类型：
--
作者：
Gibori,G;Jayatilak,PG;Khan,I;Rigby,B;Puryear,T;Nelson,S;Herz,Z
蜕膜组织是子宫内膜细胞增殖、肥大和分化的结果。在一些哺乳动物物种中，子宫内膜基质的蜕膜化伴随着植入。人类和其他灵长类动物表现出这种现象，而几种啮齿动物，其中老鼠就是一个很好的例子，表现出显着的程度（De Feo，1967）。在人类中，蜕膜化通常在每个月经周期发生。在包括大鼠在内的其他物种中，除非对敏感的子宫施加刺激，否则蜕膜组织不会发育。这种刺激可能是囊胚与子宫内膜的接触，也可能是对子宫的人工刺激（Lobel 等，1965）。然而，大鼠子宫的反应能力取决于基本激素序列的完成：暴露于黄体酮至少 48 小时，并在此期间结束时暴露于微量雌激素（Psychoyos，1973；Glasser 和 McCormack，1980）。完成该序列后 20-24 小时，子宫敏感度达到峰值状态。在正常妊娠和假妊娠中，这种情况发生在第 5 天（De Feo，1967；Psychoyos，1973），此时子宫能够对引起蜕膜反应的各种刺激做出反应。基质细胞在第 5 天至第 11 天之间增殖、肥大并分化为蜕膜细胞。在此期间之后，没有看到进一步增长的证据。蜕膜组织从第 12 天开始退化，到第 15 天则出现广泛的坏死变化。
The decidual tissue is the result of proliferation, hypertrophy and differentiation of endometrial cells. Decidualization of the endometrial stroma accompanies implantation in several mammalian species. Man and other primate species exhibit this phenomenon, and several rodent species, of which the rat is a fine example, exhibit it to marked degree (De Feo, 1967). In humans, decidualization occurs normally with each menstrual cycle. In other species, including the rat, decidual tissue does not develop unless a stimulus is applied to a sensitized uterus. This stimulus may be either the contact of the blastocyst with the endometrium or artificial stimulation of the uterus (Lobel et al., 1965). The ability of the rat uterus to respond, however, depends on the completion of a basic hormonal sequence: exposure to progesterone for at least 48 h and to a minute amount of estrogen at the end of this period (Psychoyos, 1973; Glasser and McCormack, 1980). A state of peak uterine sensitivity then results 20–24 h following the completion of this sequence. In normal pregnancy and pseudopregnancy this occurs on day 5 (De Feo, 1967; Psychoyos, 1973), at which time the uterus is capable of responding to a variety of stimuli which elicit the decidual response. Stromal cells proliferate, hypertrophy and differentiate into decidual cells between the 5th and 11th day. Following this period, no evidence for further growth is seen. Regression of the decidual tissue begins on day 12 and necrotic changes are extensive by day 15.